gene 907 words KG: STK11 2026-03-24
kind:genesection:genesstate:published
Contents

STK11 - Serine/Threonine Kinase 11

🧬 Gene Info
Gene SymbolSTK11
Full NameSerine/Threonine Kinase 11
AliasesPage for STK11, Page for STK11 Protein
Chromosome19p13.3
Protein TypeProtein
Functionis a serine/threonine kinase that functions as a master regulator of cellular energy metabolism and stress responses.
Primary Expressionmammalian tissues with particularly high levels in the brain, liver, and skeletal muscle
Molecular Weight48.6 kDa
Amino Acids433 aa
Exons9
PathwaysAMPK, AMPK pathway, AMPK Pathway
UniProt IDSearch UniProt
GeneCardsSTK11
Human Protein AtlasSTK11
Associated DiseasesALS, Alzheimer, Cancer, Parkinson, multiple sclerosis
Known Drugs/CompoundsCrocetin, rapamycin
InteractionsMAPT, PTEN, RB1, ULK1, TAU, MTOR
KG Connections300 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (10)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
APOE-Dependent Autophagy Restoration
Score: 0.61
Digital Twin-Guided Metabolic Reprogramming
Score: 0.61
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.57
Astroglial Gap Junction Coordination via Connexin-43 Phospho
Score: 0.50

Related Analyses (4)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (9)

Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
ATM Gene
gene · KG edge: associated_with
ATG14 Gene
gene · KG edge: regulates
ar
gene · KG edge: activates

Knowledge Graph (12 edges)

STK11 regulates PI3K_AKT_MTOR_pathway
STK11 associated_with VIM
STK11 regulates BECN1
STK11 associated_with HDAC6
STK11 regulates GAPDH
STK11 associated_with MAP1LC3B
STK11 associated_with MAP3K5
STK11 associated_with UVRAG
STK11 regulates H2AX
STK11 associated_with OCLN