protein 1,353 words KG: DNAJC5 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

DNAJC5 Protein

🔬 Protein Info
Gene SymbolDNAJC5
Chromosome10q24.32
Protein FamilyDnaJ/Hsp40 co-chaperone family
Protein TypeChaperone
Functionis a synaptic molecular chaperone essential for neuronal function and survival.
Subcellular LocalizationSynaptic vesicles, plasma membrane, cytoplasm
Molecular Weight22.4 kDa
Amino Acids198 aa
Exons6
UniProt IDQ9H3X5
NCBI Gene ID80331
Ensembl IDENSG00000170584
GeneCardsDNAJC5
Human Protein AtlasDNAJC5
Associated DiseasesALS, Huntington, adult-onset neuronal ceroid lipofuscinosis, disease, neurodegeneration
InteractionsROCK2, CALB2, Rb, Actin, App, STXBP1
KG Connections57 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (5)

Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.41
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.39
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.35

Related Analyses (6)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

See Also (8)

huntington-disease-treatment
therapeutic · KG edge: regulates
Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: interacts_with
Packard Center for ALS Research
institution · KG edge: associated_with
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: interacts_with
CALB2 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

DNAJC5 regulates ATG7
DNAJC5 regulates VAMP7
DNAJC5 regulates UBIQUITIN
DNAJC5 regulates RAB27A
DNAJC5 causes adult-onset neuronal ceroid lipofuscinosis
DNAJC5 interacts_with Synaptic Vesicle
DNAJC5 activates ROCK2
DNAJC5 activates CALB2
DNAJC5 interacts_with Rb
DNAJC5 activates neurodegeneration