protein 2,396 words KG: ATG7
Contents

ATG7 Protein — Autophagy-Related Protein 7

🔬 Protein Info
Gene SymbolATG7
Full Nameatg7
Chromosome3p22.1
Protein TypeProtein
Functionis an essential E1-like activating enzyme that plays a central role in the execution of macroautophagy.
Molecular Weight78 kDa
PathwaysAngiogenesis, Apoptosis, Autophagy, Camp Signaling, Cell Cycle
UniProt IDO95352
NCBI Gene ID9459
Ensembl IDENSG00000198271
OMIM607760
GeneCardsATG7
Human Protein AtlasATG7
Associated DiseasesALS, Aging, Alzheimer, Amyotrophic Lateral Sclerosis, Ataxia
Known Drugs/CompoundsRAPAMYCIN, CURCUMIN, curcumin, nicotinamide, rapamycin
InteractionsJUN, SQSTM1, MAP2, SYN1, MAP1LC3B, SNAP25
KG Connections1342 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (30)

Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
Circadian-Synchronized Proteostasis Enhancement
Score: 0.58
Circadian Clock-Autophagy Synchronization
Score: 0.55
Senescent Cell Mitochondrial DNA Release
Score: 0.54
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.39

Related Analyses (16)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (4)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: degrades
AIF1 Gene
gene · KG edge: associated_with
ACTB Gene
gene · KG edge: activates
ACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Memb
gene · KG edge: associated_with

Knowledge Graph (12 edges)

ATG7 activates ENDOTHELIAL_IMPAIRMENT
ATG7 activates JUN
ATG7 activates SQSTM1
ATG7 activates MAP2
ATG7 activates SYN1
ATG7 associated_with CTSD
ATG7 activates MAP1LC3B
ATG7 activates SNAP25
ATG7 associated_with CTSB
ATG7 activates SYT1