protein 740 words KG: DR5 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

D5 Dopamine Receptor Protein

🔬 Protein Info
Gene SymbolDR5
Chromosome4p16.1
Protein TypeReceptor
Functionis an important component in the neurobiology of neurodegenerative diseases.
Subcellular Localization</th><td>Plasma membrane, dendritic spines</td></tr>
Molecular Weight52.9 kDa
Amino Acids477 aa
PathwaysAkt, Apoptosis, Cell Cycle, Pi3K
UniProt IDP21918
NCBI Gene ID1816
Ensembl IDENSG00000169679
GeneCardsDR5
Human Protein AtlasDR5
Associated DiseasesALS
InteractionsEGFR, BAD, AKT, JUN, PI3K, JNK
KG Connections106 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (7)

Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.62
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.47
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.43
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42

Related Analyses (11)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived

See Also (5)

CD44 - Cell Surface Glycoprotein
gene · KG edge: therapeutic_target
BAD Gene - BCL2-Associated Agonist of Cell Death
gene · KG edge: inhibits
ABCG2 (BCRP) - ATP Binding Cassette Subfamily G Member
gene · KG edge: therapeutic_target
ABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member
gene · KG edge: therapeutic_target
Apoptosis in Neurodegeneration
entity · KG edge: activates

Knowledge Graph (12 edges)

DR5 activates EGFR
DR5 inhibits BAD
DR5 inhibits AKT
DR5 activates JUN
DR5 activates PI3K
DR5 inhibits PI3K
DR5 inhibits JUN
DR5 inhibits JNK
DR5 therapeutic_target TRAIL
DR5 activates TRAIL