| Gene Symbol | GAIN |
| Full Name | GAIN - GABA-A Receptor Associated Protein Like 2 |
| Aliases | Page for GAIN Gene, GABARAPL2 |
| Chromosome | 16p13.3 |
| Protein Type | Gene |
| Function | encodes a protein belonging to the GABA-A receptor-associated protein (GABARAP) family. |
| Primary Expression | various tissues with high expression in: - Brain (particularly in neurons) - Heart - Skeletal muscle |
| Pathways | Akt, Apoptosis, Autophagy, Cell Cycle, Cholesterol Metabolism |
| NCBI Gene ID | 124454 |
| GeneCards | GAIN |
| Human Protein Atlas | GAIN |
| N-terminal Glycine | Required for lipidation (conjugation with phosphatidylethanolamine) |
| Ubiquitin-like Domain | Characteristic of ATG8 family proteins |
| C-terminal Region | Variable, determines protein-protein interactions |
| Lipidation | GAIN undergoes lipidation at its N-terminal glycine, converting to a membrane-bound form (GABARAPL2-II) |
| Associated Diseases | aging, Als, Alzheimer, Alzheimer'S Disease, Amyotrophic Lateral Sclerosis |
| Interactions | ACAT1, ACC, ACHE, Actin, AGING, AIF |
| KG Connections | 1870 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |
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