protein 673 words KG: GAINPROTEIN 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

GAIN Protein (GABARAPL2) - GABA-A Receptor Associated Protein Like 2

🔬 Protein Info
Gene SymbolGAIN
Full NameGAIN (GABARAPL2) - GABA-A Receptor Associated Like 2
AliasesPage for GAIN Gene, GABARAPL2
Chromosome16p13.3
Protein TypeGene
Functionencodes a protein belonging to the GABA-A receptor-associated protein (GABARAP) family.
Primary Expressionvarious tissues with high expression in: - Brain (particularly in neurons) - Heart - Skeletal muscle
PathwaysAkt, Apoptosis, Autophagy, Cell Cycle, Cholesterol Metabolism
UniProt IDSearch UniProt
NCBI Gene ID124454
GeneCardsGAIN
Human Protein AtlasGAIN
Associated DiseasesALS, Aging, Alzheimer, Alzheimer'S Disease, Amyotrophic Lateral Sclerosis
InteractionsTKT, GABRA1, ALOX15, HNRNPA2B1, HNRNPA1, OVERVIEW
KG Connections1953 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (22)

TREM2-Dependent Microglial Senescence Transition
Score: 0.69
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.66
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.62
PARP1 Inhibition Therapy
Score: 0.58
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.57

Related Analyses (17)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in