| Gene Symbol | HMGB1 |
| Full Name | High Mobility Group Box 1 |
| Chromosome | 13q12.3 |
| Protein Family | HMG-box superfamily |
| Function | is a gene on chromosome 13q12. |
| Primary Expression | Ubiquitous; enriched in neurons, microglia, astrocytes |
| Subcellular Localization | Nucleus, cytoplasm, extracellular (secreted DAMP) |
| Molecular Weight | 25 kDa |
| Amino Acids | 215 aa |
| Exons | 5 |
| Pathways | Adaptive Immunity, Akt, Autophagy Machinery, Ferroptosis, Mapk |
| UniProt ID | P09429 |
| NCBI Gene ID | 3146 |
| Ensembl ID | ENSG00000189403 |
| OMIM | 163905 |
| GeneCards | HMGB1 |
| Human Protein Atlas | HMGB1 |
| Associated Diseases | ALS, Aging, Alzheimer, Anxiety-like behavior, CANCER |
| Known Drugs/Compounds | RAPAMYCIN, Trilobatin, curcumin, resveratrol, Omega-3 Polyunsaturated Fatty Acids, Box-A |
| Interactions | EGF, MLST8, RICTOR, MTOR, PIK3C3, EGFR |
| KG Connections | 1279 knowledge graph edges |
| Databases | GeneCardsHPASTRING |