protein 1,175 words KG: IL1R1 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

Interleukin-1 Receptor Type 1 Protein

🔬 Protein Info
Gene SymbolIL1R1
Full NameInterleukin 1 Receptor Type 1
Chromosome2q12
Protein TypeReceptor
FunctionIL-1R1 mediates the potent pro-inflammatory effects of IL-1 cytokines in the central nervous system:
Subcellular Localization</b></td><td>Cell membrane (type I transmembrane)</td></tr>
Molecular Weight80 kDa
Amino Acids319 aa
PathwaysNF-κB, MAPK
UniProt ID[P01589](https://www.uniprot.org/uniprot/P01589)
Ensembl IDENSG00000115594
GeneCardsIL1R1
Human Protein AtlasIL1R1
Associated DiseasesAls, Infection, Inflammation, disease
InteractionsSERPINA3, Rb, Il-10, TNFR1, IFN, Interleukin
KG Connections60 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (7)

Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.62
APOE-Dependent Autophagy Restoration
Score: 0.61
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.47
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42

Related Analyses (9)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (5)

Packard Center for ALS Research
institution · KG edge: activates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: expressed_in
Genes
index · KG edge: contributes_to
Astrocytes
entity · KG edge: expressed_in
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: associated_with

Knowledge Graph (12 edges)

IL1R1 activates SERPINA3
IL1R1 expressed_in S100A9
IL1R1 contributes_to Encephalitis
IL1R1 associated_with Nfkb
IL1R1 expressed_in Rb
IL1R1 activates Rb
IL1R1 activates Il-10
IL1R1 activates TNFR1
IL1R1 activates neuroinflammation
IL1R1 expressed_in NEUROINFLAMMATION