protein 606 words KG: LRP4 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

LRP4 Protein

🔬 Protein Info
Gene SymbolLRP4
AliasesPage for LRP4 Protein
Chromosome11p11.2
Protein TypeReceptor
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight195 kDa
Amino Acids1725 aa
Exons33
PathwaysWnt signaling, Wnt
UniProt ID[Q9NPJ6](https://www.uniprot.org/uniprot/Q9NPJ6)
Ensembl IDENSG00000134538
GeneCardsLRP4
Human Protein AtlasLRP4
Associated DiseasesALS, Aging, Atherosclerosis, Cancer, Cardiovascular
InteractionsWNT, CANCER, PAH
KG Connections70 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (7)

Circadian-Synchronized LRP1 Pathway Activation
Score: 0.53
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.44
LRP1-Dependent Tau Uptake Disruption
Score: 0.44

Related Analyses (8)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived

See Also (7)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: associated_with
LRP1-Enhanced Perivascular Drainage Therapy
idea · KG edge: associated_with
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: associated_with
LRP2 — Low Density Lipoprotein Receptor-Related Protein
gene · KG edge: associated_with

Knowledge Graph (12 edges)

LRP4 associated_with PAH
LRP4 associated_with LDLR
LRP4 associated_with LRP5
LRP4 associated_with LRP1
LRP4 associated_with LRP8
LRP4 associated_with LRP2
LRP4 associated_with REELIN
LRP4 associated_with LRP1B
LRP4 therapeutic_target OVERVIEW
LRP4 therapeutic_target CD4