gene 680 words KG: PAH 2026-03-13
kind:genesection:genesstate:published
Contents

PAH Gene

🧬 Gene Info
Gene SymbolPAH
Full NamePAH
Chromosome12q23.2
Protein TypeGene
FunctionPAH catalyzes the hydroxylation of phenylalanine to tyrosine
Primary Expressionthe liver but is also expressed in the kidney and brain
Amino Acids527 aa
PathwaysApoptosis
NCBI Gene IDSearch NCBI
GeneCardsPAH
Human Protein AtlasPAH
Associated DiseasesALS, Aging, Alzheimer, Atherosclerosis, Autism
InteractionsLDLR, GFAP, LRP4, LRP8, LRP5, LRP1
KG Connections207 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Knowledge Graph

Related Hypotheses (5)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.52
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
LRP1-Dependent Tau Uptake Disruption
Score: 0.44
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.44

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (14)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
EPAS1 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

PAH activates LDLR
PAH associated_with LRP4
PAH associated_with LRP5
PAH associated_with LRP1
PAH associated_with LRP8
PAH associated_with LRP2
PAH regulates KCNK1
PAH regulates KCNK3
PAH regulates KCNK6
PAH regulates KCNK2