gene 1,319 words KG: LRP4 2026-03-28
kind:genesection:genesstate:published
Contents

LRP4 — Low Density Lipoprotein Receptor-Related Protein 4

🧬 Gene Info
Gene SymbolLRP4
Full NameLow Density Lipoprotein Receptor-Related Protein 4
AliasesPage for LRP4 Protein
Chromosome11p11.2
Protein TypeReceptor
Functionis an important component in the neurobiology of neurodegenerative diseases.
Subcellular LocalizationCell membrane (postsynaptic), endosomes
Molecular Weight~195 kDa
Amino Acids1725 amino acids
Exons33
Gene TypeProtein coding
PathwaysWnt signaling, Wnt
UniProt IDQ9NZU0
NCBI Gene ID4038
Ensembl IDENSG00000134538
OMIM604270
GeneCardsLRP4
Human Protein AtlasLRP4
Associated DiseasesALS, Aging, Atherosclerosis, Cancer, Cardiovascular
InteractionsWNT, CANCER, PAH
KG Connections70 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (16)

Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.62
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.53

Related Analyses (9)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived

See Also (9)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: activates
LRP1-Enhanced Perivascular Drainage Therapy
idea · KG edge: associated_with
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: associated_with
Autoimmune Hypothesis in Alzheimer's Disease
hypothesis · KG edge: therapeutic_target

Knowledge Graph (12 edges)

LRP4 associated_with PAH
LRP4 associated_with LDLR
LRP4 associated_with LRP5
LRP4 associated_with LRP1
LRP4 associated_with LRP8
LRP4 associated_with LRP2
LRP4 associated_with REELIN
LRP4 associated_with LRP1B
LRP4 therapeutic_target OVERVIEW
LRP4 therapeutic_target CD4