protein 2,891 words KG: MAPK3PROTEIN 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

ERK1 Protein

🔬 Protein Info
Gene SymbolMAPK3
Full NameMitogen-Activated Protein Kinase 3
AliasesPage for MAPK3 Gene
Chromosome16p11.2
Protein FamilyMAP kinase family, CMGC group
Protein TypeKinase
Functionis a serine/threonine protein kinase encoded by the MAPK3 gene.
Subcellular LocalizationCytoplasm, Nucleus
Molecular Weight43 kDa
Amino Acids379 aa
PathwaysMAPK, mapk
UniProt IDP27361
GeneCardsMAPK3
Human Protein AtlasMAPK3
Associated DiseasesALS, Aging, Alzheimer, Atherosclerosis, Cancer
InteractionsNLRP3, ZAP70, TP53, CD19, EEF2, CCL5
KG Connections444 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (7)

Senescence-Associated Myelin Lipid Remodeling
Score: 0.51
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.50
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
APOE-Dependent Autophagy Restoration
Score: 0.61
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51

Related Analyses (8)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived

Related Experiments (6)

GPR109A receptor validation using knockout macrophages
exploratory · proposed · Score: 0.92
MAPK pathway inhibition by QTJD through butyrate mechanism
exploratory · proposed · Score: 0.90
TBK1-PAK1IP1-PAK1 signaling pathway analysis
exploratory · proposed · Score: 0.90
Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
Proposed experiment from debate on Perivascular spaces and g
falsification · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in