protein 1,147 words KG: NEAT1 2026-03-26
kind:proteinsection:proteinsstate:published
Contents

NEAT1 (Nuclear Enriched Abundant Transcript 1)

🔬 Protein Info
Gene SymbolNEAT1
Chromosome11q13.1
Functionis a nuclear long non-coding RNA that serves as the essential structural scaffold for paraspeckles — nuclear bodies involved in gene expression regulation.
Primary ExpressionUbiquitous, highest in brain, heart, muscle
Subcellular LocalizationNucleus (paraspeckles)
Molecular Weight~23 kDa (isoform 1), ~20 kDa (isoform 2)
PathwaysBlood-Brain Barrier, Endocytosis, Epigenetic, Microrna, Oxidative Stress
GeneCardsNEAT1
Human Protein AtlasNEAT1
RNA TypeLong non-coding RNA (lncRNA)
GeneNEAT1
RNA Length~23 kb (isoform 1), ~3.7 kb (isoform 2)
Associated DiseasesALS, Alzheimer's disease, Amyotrophic Lateral Sclerosis, Atherosclerosis, Colorectal Cancer, Huntington's disease
InteractionsPPARG, CDK2, JUN, TDP-43, SRPK1, CD163
KG Connections299 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (13)

Cryptic Exon Silencing Restoration
Score: 0.46
Circadian-Synchronized Proteostasis Enhancement
Score: 0.58
Circadian Clock-Autophagy Synchronization
Score: 0.55
Phase-Separated Organelle Targeting
Score: 0.52
Temporal Decoupling via Circadian Clock Reset
Score: 0.52

Related Analyses (6)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived

See Also (11)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: inhibits
Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
ATG5 — Autophagy Related 5
gene · KG edge: associated_with

Knowledge Graph (12 edges)

NEAT1 regulates TDP-43
NEAT1 associated_with CTSD
NEAT1 associated_with TNFRSF21
NEAT1 associated_with ATG5
NEAT1 expressed_in GAPDH
NEAT1 activates PPARG
NEAT1 interacts_with CDK2
NEAT1 expressed_in Motor Neuron
NEAT1 interacts_with JUN
NEAT1 associated_with TAU