| Gene Symbol | NME8PROTEIN |
| Protein Type | Kinase |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | various brain regions:
- Cerebellum: Purkinje cells
- Hippocampus: Pyramidal neurons
- [C |
| Molecular Weight | 20 kDa |
| GeneCards | NME8PROTEIN |
| Human Protein Atlas | NME8PROTEIN |
| Oligomeric state | Hexamer (NDPK domain) |
| Active sites | His-118 (NDPK), Cys-256/Cys-259 (Trx) |
| Post-translational modifications | Phosphorylation, oxidation |
| Binding partners | Tubulin, cytoskeletal proteins |
| Strategy | Agent |
| Gene therapy | AAV-NME8 |
| Antioxidants | N-acetylcysteine |
| Redox modulators | Thioredoxin mimetics |
| Associated Diseases | Als, Alzheimer, Ms |
| Interactions | PTK2B, ZCWPW1, ABCA7, GAB2, MS4A4E, CLU |
| KG Connections | 73 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |