protein 760 words KG: PLP1 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

PLP1 Protein

🔬 Protein Info
Gene SymbolPLP1
Protein FamilyProteolipid protein family
FunctionPLP1 is essential for multiple aspects of CNS myelination:
Primary ExpressionCNS (not PNS)
Subcellular LocalizationMyelin sheath, oligodendrocyte plasma membrane
Molecular Weight30 kDa
Amino Acids35 aa
PathwaysPhagocytosis
UniProt ID[P60228](https://www.uniprot.org/uniprot/P60228)
GeneCardsPLP1
Human Protein AtlasPLP1
Associated DiseasesALS, Alzheimer, Ms, Parkinson, Pelizaeus-Merzbacher disease, dementia
Known Drugs/CompoundsRESVERATROL, CURCUMIN
InteractionsMBP, HSPA1A, GFAP, ST3GAL5, MAG, OLIG1
KG Connections169 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (5)

GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.52
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Oligodendrocyte Protectin D1 Mimetic for Myelin Resolution
Score: 0.45
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.35

Related Analyses (7)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (9)

Curcumin for Neurodegeneration
therapeutic · KG edge: interacts_with
Dementia Australia
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: interacts_with
GALC Gene
gene · KG edge: causes

Knowledge Graph (12 edges)

PLP1 causes Pelizaeus-Merzbacher disease
PLP1 activates MBP
PLP1 activates HSPA1A
PLP1 upregulates Parkinson's Disease Dementia
PLP1 modulates axonal ATP levels
PLP1 associated_with compound action potential
PLP1 implicated_in spastic paraplegia
PLP1 contributes_to myelin structural integrity
PLP1 inhibits MBP
PLP1 inhibits GFAP