protein 1,635 words KG: TGFB1PROTEIN 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

TGF-β1 Protein

🔬 Protein Info
Gene SymbolTGF
Full Nameβ1 Protein
AliasesTGFB1PROTEIN
FunctionTGF-β Receptor 1 (TGFBR1) is a transmembrane serine/threonine kinase that serves as the primary type I receptor for transforming growth factor-beta ligands in the nervous system.
Molecular Weight~56 kDa
Amino Acids503 amino acids
Pathwaysunfolded protein response, TGF-beta signaling, neurotrophin signaling, NF-kB signaling, oxidative stress response
GeneCardsTGF
Human Protein AtlasTGF
Associated DiseasesALS, Alzheimer, Alzheimer's disease, cancer, cardiovascular disease, glioblastoma
Known Drugs/Compoundscurcumin, rapamycin
InteractionsTNF, TGFBR1, TGFBR2, TGFB, TRPV4, VEGF
KG Connections252 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (7)

Ocular Immune Privilege Extension
Score: 0.47
Microbiome-Derived Tryptophan Metabolite Neuroprotection
Score: 0.41
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.52
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Oligodendrocyte Protectin D1 Mimetic for Myelin Resolution
Score: 0.45

Related Analyses (8)

Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (11)

miRNomic profiling and TGF-β content analysis in sEV
exploratory · proposed · Score: 0.90
ROC curve analysis for predicting sEV ineffectiveness
clinical · proposed · Score: 0.90
ROC analysis for sEV effectiveness prediction
clinical · proposed · Score: 0.90
miRNomic profiling and TGF-β content analysis in sEV
exploratory · proposed · Score: 0.85
s:** - GPR32 knockout in microglia should worsen neuroinflam
falsification · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in