| Gene Symbol | TLR4 |
| Full Name | Toll-Like Receptor 4 |
| Chromosome | 9q33.1 |
| Protein Type | Receptor |
| Target Class | Receptor |
| Function | LBP transfer: LPS-binding protein transfers LPS to CD14 |
| Mechanism of Action | Small molecule antagonist or antibody blocking TLR4-mediated neuroinflammatory signaling |
| Subcellular Localization | </strong></td><td>Plasma membrane, endosomes</td></tr> |
| Druggability | Low (0.41) |
| Clinical Stage | Phase III |
| Molecular Weight | 95 kDa |
| Pathways | Akt, Amyloid, Apoptosis, Autophagy, Cell Division |
| UniProt ID | O00206 |
| NCBI Gene ID | 7099 |
| Ensembl ID | ENSG00000136869 |
| OMIM | 603030 |
| GeneCards | TLR4 |
| Human Protein Atlas | TLR4 |
| Associated Diseases | Aging, Als, Alzheimer, Alzheimer's disease |
| Known Drugs/Compounds | DHT, DOXORUBICIN, Eritoran, Ezetimibe, FREE HEME, Gastrodin |
| Interactions | ABETA, ACAT1, Actin, AD, AGING, AHR |
| SciDEX Target | View Target Profile (4 clinical trials) |
| SciDEX Hypotheses | Selective TLR4 Modulation to Prevent Gut-Derived N Gut-Brain Axis Microglial Depriming Strategy Gut Barrier Restoration to Prevent Bacterial Trans |
| KG Connections | 2313 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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