protein 534 words KG: UNC13A 2026-03-14
kind:proteinsection:proteinsstate:published
Contents

UNC13A Protein

🔬 Protein Info
Gene SymbolUNC13A
Full NameUnc-13 Homolog A
AliasesMunc13-1
Chromosome19p13.11
FunctionSynaptic vesicle priming factor essential for neurotransmitter release
Primary ExpressionPresynaptic terminals, Motor Neurons, Cortical Neurons, Hippocampus
Subcellular Localization</td><td>Synaptic vesicle presynaptic terminal</td></tr>
Molecular Weight194.3 kDa
Amino Acids1703
PathwaysSynaptic vesicle exocytosis, Neurotransmitter release
UniProt IDQ9UPW8
Ensembl IDENSG00000130477
GeneCardsUNC13A
Human Protein AtlasUNC13A
Associated DiseasesALS, Alzheimer, Amyotrophic Lateral Sclerosis, Dementia, Depletion
InteractionsTDP-43, NEURODEGENERATIVE DISEASES, SYNAPSE, DEMENTIA, amyotrophic lateral sclerosis, RNA
KG Connections198 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (8)

Arginine Methylation Enhancement Therapy
Score: 0.46
Cryptic Exon Silencing Restoration
Score: 0.46
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42
PARP1 Inhibition Therapy
Score: 0.58
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Packard Center for ALS Research
institution · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: associated_with
ANO9 — Anoctamin 9
gene · KG edge: implicated_in
Amyotrophic Lateral Sclerosis
redirect · KG edge: activates
Wnt/β-Catenin Signaling Pathway in Neurodegeneration
mechanism · Pages share 3 hypotheses

Knowledge Graph (12 edges)

UNC13A regulates ANO9
UNC13A regulates TBK1
UNC13A associated_with Depletion
UNC13A expressed_in TDP43
UNC13A associated_with Cryptic Donor Splice Site
UNC13A causes TDP-43
UNC13A expressed_in TDP-43
UNC13A regulates RBPJL
UNC13A regulates C3AR1
UNC13A associated_with GRN