protein 619 words KG: VPS16 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

VPS16 Protein

🔬 Protein Info
Gene SymbolVPS16
Full NameVacuolar Protein Sorting 16 Homolog
Chromosome20q13.33
FunctionIn neurons, VPS16 and the HOPS complex play essential roles in
Molecular Weight89 kDa
Amino Acids790 aa
UniProt IDQ9H269
NCBI Gene ID64601
Ensembl IDENSG00000112357
GeneCardsVPS16
Human Protein AtlasVPS16
HOPS ComplexMulti-subunit tethering complex containing VPS11, VPS18, VPS33
Rab7 GTPaseKey effector of VPS16-mediated trafficking
Autophagy-Lysosomal PathwayVPS16-dependent
Associated Diseasescolorectal cancer, dystonia
InteractionsLC3, VPS33A, UVRAG, STX17, AND, LYSOSOME
KG Connections26 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (4)

Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Autophagosome Maturation Checkpoint Control
Score: 0.49
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.35

Related Analyses (6)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

See Also (14)

Ras-MAPK Signaling Pathway in Neurodegeneration
mechanism · KG edge: activates
Lysosome Dysfunction in Neurodegeneration
mechanism · KG edge: interacts_with
Packard Center for ALS Research
institution · KG edge: interacts_with
VPS33A Gene
gene · KG edge: inhibits
UVRAG Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

VPS16 inhibits LC3
VPS16 component_of HOPS
VPS16 causes dystonia
VPS16 associated_with colorectal cancer
VPS16 component_of CORVET
VPS16 participates_in endosome
VPS16 inhibits VPS33A
VPS16 interacts_with UVRAG
VPS16 inhibits STX17
VPS16 associated_with COX15