gene 2,512 words KG: AXL 2026-03-26
kind:genesection:genestopic:alzheimerstopic:parkinsonstopic:neuroinflammation
Contents

AXL - AXL Receptor Tyrosine Kinase

🧬 Gene Info
Gene SymbolAXL
Full NameAXL - AXL Receptor Tyrosine Kinase
AliasesPage for AXL Protein
Chromosome19q13.2
Protein TypeGene
Functionis a receptor tyrosine kinase belonging to the TAM family (TYRO3, AXL, MERTK) that plays critical roles in cell survival, migration, immune regulation, and tissue homeostasis[@graham2014].
Primary Expressionimmune cells, endothelial cells, neurons, and various peripheral tissues, where it mediates both ligand-dependent and ligand-independent signaling cas
Molecular Weight140 kDa
Amino Acids985 aa
Exons20
PathwaysNF-ÎșB, PI3K, MAPK
UniProt IDQ9U6C5
NCBI Gene ID55768
Ensembl IDENSG00000167601
GeneCardsAXL
Human Protein AtlasAXL
Associated DiseasesAging, Alzheimer, Cancer, INFLAMMATION, Ms, NEUROINFLAMMATION
InteractionsCHIT1, CXCL10, MMP12, CXCL1, EZH2, BRAF
KG Connections201 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Knowledge Graph (12 edges)

AXL downregulates CHIT1
AXL provides_data_for ds-83b31ef18d49
AXL therapeutic_target MMP12
AXL inhibits CHIT1
AXL therapeutic_target CXCL1
AXL therapeutic_target CXCL10
AXL inhibits CXCL10
AXL inhibits MMP12
AXL inhibits CXCL1
AXL associated_with GAS6