gene 2,049 words KG: CXCL1 2026-03-28
kind:genesection:genesstate:published
Contents

CXCL1

🧬 Gene Info
Gene SymbolCXCL1
AliasesC-X-C motif chemokine ligand 1 (GROα)
Protein TypeReceptor
Primary Expressionblood-brain barrier
Amino Acids107 aa
PathwaysChemoresistance, Cholesterol, Tnf Signaling, Toll-Like Receptor, Tumor Microenvironment
Ensembl IDENSG00000163425
GeneCardsCXCL1
Human Protein AtlasCXCL1
Associated DiseasesAlzheimer, Inflammation, Ms, Neuroinflammation, Pancreatic Cancer, Rheumatoid Arthritis
Known Drugs/Compoundsrapamycin
InteractionsCLDN5, OCLN, IL23A, CXCL10, MMP12, CXCL2
KG Connections468 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (20)

SASP-Driven Aquaporin-4 Dysregulation
Score: 0.59
Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.68
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
SASP-Mediated Cholinergic Synapse Disruption
Score: 0.56

Related Analyses (7)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived

Related Experiments (1)

Electroacupuncture ST37 treatment for DSS-induced colitis in
validation · proposed · Score: 0.95

See Also (8)

Alzheimer Indonesia
institution · KG edge: regulates
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: regulates
AXL - AXL Receptor Tyrosine Kinase
gene · KG edge: inhibits
ATF4 Gene
gene · KG edge: activates
ANG — Angiogenin
gene · KG edge: associated_with

Knowledge Graph (12 edges)

CXCL1 activates CXCL2
CXCL1 activates IL12B
CXCL1 activates IL23A
CXCL1 activates IL6
CXCL1 activates OCLN
CXCL1 biomarker_for CXCL10
CXCL1 biomarker_for MMP12
CXCL1 treats DEPRESSION
CXCL1 therapeutic_target DDIT3
CXCL1 inhibits CLDN5