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mechanism 1,124 words KG: SARM1
Contents

sarm1-programmed-axon-degeneration

⚙ Mechanism Info
NameSARM1
Key Genes/ProteinsALZHEIMER, ALZHEIMER'S DISEASE, AND, APOPTOSIS, AUTOPHAGY
Related DiseasesAging, Als, Alzheimer, Alzheimer's disease, Alzheimer's Disease
Related PathwaysApoptosis, Autophagy
Linked Hypotheses3 hypotheses

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Related Hypotheses (3)

SARM1-Mediated NAD+ Depletion as Terminal Executor of MCT1-D
Score: 0.70Pharmacologic SARM1 blockade to prevent Wallerian degenerati
Score: 0.66NAD+/SARM1 Axis Provides Metabolic Feedback Coupling Mitopha
Score: 0.58

Knowledge Graph (12 edges)

SARM1 activates axonal degeneration
SARM1 regulates neuroinflammation
SARM1 associated_with Alzheimer's disease
SARM1 expressed_in hippocampal neurons
TNF inhibits SARM1
NAD activates SARM1
APOPTOSIS activates SARM1
AXON activates SARM1
BAX activates SARM1
SARM1 activates DLK

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