therapeutic 1,763 words KG: ent-gene-83d99ff1 2026-03-23
kind:therapeuticsection:therapeuticsstate:publishedevidence:strong
Contents

FUS-Targeting Therapies for Amyotrophic Lateral Sclerosis

🔬 Protein Info
Gene SymbolFUS
Full NameTargeting Therapies for Amyotrophic Lateral Sclerosis
Chromosome16p11.2.
Protein TypeProtein
Functionis an important component in the neurobiology of neurodegenerative diseases.
PathwaysBlood-Brain Barrier, Hippo Pathway, Oxidative Stress, Sod1, Tdp-43
UniProt IDSearch UniProt
GeneCardsFUS
Human Protein AtlasFUS
Associated DiseasesAD, ALI, ALS, AMI, Aging
Known Drugs/CompoundsAntisense Oligonucleotide, ADUCANUMAB, RNA oligonucleotides, Rna Oligonucleotides
InteractionsTARDBP, LC3, ACTB, G3BP1, BCL2, C9ORF72
SciDEX HypothesesASO-Mediated Exon Skipping to Restore FUS-TAZ Chap
KG Connections1526 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (21)

Targeting Bacterial Curli Fibrils to Prevent α-Synuclein Cro
Score: 0.49
Trinucleotide Repeat Sequestration via CRISPR-Guided RNA Tar
Score: 0.48
Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.39

Related Analyses (19)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · completed
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · archived
Microglial subtypes in neurodegeneration — friend vs foe
neuroscience · failed

Related Experiments (8)

s:** - Single-cell RNA-seq to measure editing efficiency acr
falsification · proposed · Score: 0.40
ALS Regional Onset and Spread: Network-Level Staging Model
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
TDP-43 PET Ligand Development for FTD and ALS
clinical · proposed · Score: 0.40
Alpha-Synuclein Seed Amplification Assay Validation
clinical · proposed · Score: 0.40

Key Papers (1)

Using dynamic monitoring of choices to predict and understand risk pre
Proceedings of the National Ac 2021

See Also (15)

Wnt/β-Catenin Signaling Pathway in Neurodegeneration
mechanism · Pages share 3 hypotheses
WNK1-Bilirubin Signaling in Neuroinflammation and Neuro
mechanism · Pages share 3 hypotheses
vip-vasoactive-intestinal-peptide-signaling-neurodegene
mechanism · Pages share 3 hypotheses
VEGF Signaling and Cerebral Angiogenesis in Neurodegene
mechanism · Pages share 3 hypotheses
Vagus Nerve Pathway in Neurodegeneration
mechanism · Pages share 3 hypotheses

Knowledge Graph (2 edges)

ent-gene-83d99ff1 data_in benchmark_ot_ad_answer_key:FUS
benchmark_ot_ad_answer_key:FUS data_in ent-gene-83d99ff1