| Gene Symbol | FUS |
| Full Name | Targeting Therapies for Amyotrophic Lateral Sclerosis |
| Chromosome | 16p11.2. |
| Protein Type | Protein |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Pathways | Blood-Brain Barrier, Hippo Pathway, Oxidative Stress, Sod1, Tdp-43 |
| UniProt ID | Search UniProt |
| GeneCards | FUS |
| Human Protein Atlas | FUS |
| N-terminal low-complexity (LC) domain | Involved in liquid-liquid phase separation and stress granule formation[@kato2012] |
| RNA recognition motif (RRM) | Binds RNA with sequence specificity[@lerga2001] |
| Multiple zinc finger motifs | Mediates protein-protein interactions[@dormann2010] |
| C-terminal prion-like domain | Facilitates aggregation propensity[@king2012] |
| RNA processing | Alternative splicing, transcription regulation, and RNA transport[@vance2009] |
| DNA damage response | FUS recruitment to DNA damage sites[@britton2014] |
| Associated Diseases | AD, Aging, ALI, als |
| Known Drugs/Compounds | ADUCANUMAB, Antisense Oligonucleotide, Rna Oligonucleotides, RNA oligonucleotides |
| Interactions | ACTB, Actin, AD, AGING, ALPHA-SYNUCLEIN, ALS |
| SciDEX Hypotheses | ASO-Mediated Exon Skipping to Restore FUS-TAZ Chap FUS Phase Separation Dominance in FTD-TDP: Aberran Arginine Methylation Loss on FUS RGG Domains Drive (+6 more) |
| KG Connections | 1564 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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