concept

TRIM22

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TRIM22: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

38Connections

0Hypotheses

0Analyses

30Outgoing

8Incoming

0Experiments

0Debates

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Pathway Diagram

graph TD
    TRIM22["TRIM22"]
    TRIM22 -->|"regulates"| Autophagy["Autophagy"]
    TRIM22 -->|"mediates"| GABARAP["GABARAP"]
    TRIM22 -->|"mediates"| PLEKHM1["PLEKHM1"]
    TRIM22 -->|"involved_in"| Protein_Aggregates["Protein Aggregates"]
    TRIM22 -->|"regulates"| autophagy["autophagy"]
    TRIM22 -->|"activates"| autophagosome_lysosome_fusion["autophagosome-lysosome fusion"]
    AUTOPHAGY["AUTOPHAGY"] -->|"regulates"| TRIM22
    UBIQUITIN["UBIQUITIN"] -->|"activates"| TRIM22
    GABARAP -->|"activates"| TRIM22
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"] -->|"regulates"| TRIM22

Outgoing (30)

Target	Relation	Type	Str
Autophagosome-Lysosome Fusion	associated_with	process	0.95
Autophagy	regulates	process	0.95
GABARAP	mediates	protein	0.92
GABARAP family proteins	mediates association of	protein	0.90
PLEKHM1	mediates	protein	0.90
Protein Aggregate Clearance	associated_with	process	0.88
Early-Onset Familial Alzheimer Disease	associated_with	disease	0.85
Protein Aggregates	involved_in	phenotype	0.85
autophagy	regulates	process	0.70
GABARAP	interacts_with	protein	0.70
PLEKHM1	interacts_with	protein	0.70
autophagosome-lysosome fusion	activates	process	0.70
protein aggregates	regulates	process	0.70
Alzheimer's disease	associated_with	disease	0.70
protein aggregates	activates	protein	0.70
Alzheimer	associated_with	disease	0.65
Tumor	regulates	disease	0.65
AND	associated_with	gene	0.60
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
UBIQUITIN	activates	gene	0.60
Proteasome	regulates	pathway	0.60
AUTOPHAGY	regulates	gene	0.60
Fus	associated_with	protein	0.60
GABARAP	activates	gene	0.60
Ubiquitin-Proteasome	regulates	pathway	0.60
protein misfolding	activates	process	0.60
autophagy pathway	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
Alzheimer's disease	interacts_with	disease	0.60
neurodegeneration	regulates	disease	0.60

Incoming (8)

Source	Relation	Type	Str
LYSOSOME	associated_with	gene	0.60
ALZHEIMER DISEASE	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
AUTOPHAGY	regulates	gene	0.60
UBIQUITIN	activates	gene	0.60
GABARAP	activates	gene	0.60
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
AND	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity