concept

TUMORIGENESIS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TUMORIGENESIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

39Connections

0Hypotheses

0Analyses

0Outgoing

39Incoming

0Experiments

0Debates

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💡 Concept Info

Name	TUMORIGENESIS

Pathway Diagram

graph TD
    TUMORIGENESIS["TUMORIGENESIS"]
    HER2_Activating_Mutations["HER2-Activating Mutations"] -->|"contributes to"| TUMORIGENESIS
    HER2_amplification["HER2 amplification"] -->|"promotes"| TUMORIGENESIS
    EGFR["EGFR"] -->|"causes"| TUMORIGENESIS
    MEF2_HDAC4_Axis["MEF2-HDAC4 Axis"] -->|"involved_in"| TUMORIGENESIS
    PRMT1["PRMT1"] -->|"contributes to"| TUMORIGENESIS
    FGFR_Abnormal_Alterations["FGFR Abnormal Alterations"] -->|"contributes to"| TUMORIGENESIS

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (39)

Source	Relation	Type	Str
CGAS	associated_with	protein	0.95
HER2-Activating Mutations	contributes_to	mechanism	0.93
Her2-Activating Mutations	promotes	mechanism	0.92
HER2 amplification	promotes	phenotype	0.92
CGAS	associated_with	entity	0.90
FGFR Abnormal Alterations	contributes_to	biomarker	0.90
epigenetic regulation	contributes_to	process	0.90
PRMT1	contributes_to	entity	0.90
HDAC3	promotes	gene	0.90
EGFR	causes	gene	0.90
PRMT1	associated_with	protein	0.90
MEF2-HDAC4 Axis	involved_in	mechanism	0.90
PRMT1	mediates	protein	0.90
HMGB1	involved_in	protein	0.90
CGAS	promotes	protein	0.90
ALOX12	suppresses	gene	0.90
TP53	suppresses	gene	0.90
Fgfr Dysregulation	promotes	mechanism	0.90
Tumor Biomarkers	biomarker_for	biomarker	0.90
KLHL22	associated_with	protein	0.90
PRMT1	involved_in	gene	0.90
PI3K/Akt/mTOR	involved_in	pathway	0.90
Biomolecular Condensates	associated_with	process	0.90
HMGB1	mediates	protein	0.88
PRPS1 O-GlcNAcylation	contributes_to	process	0.85
MTOR	associated_with	entity	0.85
TFR1	involved_in	protein	0.85
HNRNPA2B1	involved_in	gene	0.85
PI3K/AKT/mTOR	associated_with	pathway	0.85
Aberrant Phase Transition	contributes_to	mechanism	0.85
DNA Repair Suppression	contributes_to	process	0.85
ANT2	implicated_in	protein	0.80
LRP1 Inhibition	inhibits	mechanism	0.80
NSD3	contributes_to	gene	0.80
cGAS	promotes	protein	0.80
GPX4	associated_with	protein	0.75
oxidative stress	activates	process	0.70
IL-6	activates	gene	0.70
SDHAF2	contributes_to	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity