Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ant2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ANT2 |
| Full Name | Adenine Nucleotide Translocator 2 (ANT2) |
| Aliases | SLC25A5 |
| Chromosome | Xq26.3 |
| Function | is a mitochondrial inner membrane protein that catalyzes the exchange of ADP and ATP across the inner mitochondrial membrane. |
| Primary Expression | most tissues, including the brain |
| Molecular Weight | 33 kDa |
| Amino Acids | 322 aa |
| UniProt ID | P02724 |
| NCBI Gene ID | 291 |
| Ensembl ID | ENSG00000148218 |
| OMIM | 300120 |
| GeneCards | ANT2 |
| Human Protein Atlas | ANT2 |
| Associated Diseases | Alzheimer's disease |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
ANT2["ANT2"]
ANT2 -->|"implicated in"| Tumorigenesis["Tumorigenesis"]
ANT2 -->|"implicated in"| Drug_Resistance["Drug Resistance"]
ANT2 -->|"regulates"| Glycolytic_ATP_Import["Glycolytic ATP Import"]
ANT2 -->|"participates in"| Blood_Cell_Development["Blood Cell Development"]
ANT2 -->|"participates in"| Gastrointestinal_Motility["Gastrointestinal Motility"]
ANT2 -->|"participates in"| Airway_Hydration["Airway Hydration"]
ANT2 -->|"participates in"| Myocardial_Development["Myocardial Development"]
ANT2 -->|"activates"| Hepatitis["Hepatitis"]
TFEB["TFEB"] -->|"activates"| ANT2| Target | Relation | Type | Str |
|---|---|---|---|
| Tumorigenesis | implicated_in | biological_process | 0.80 |
| Glycolytic ATP Import | regulates | biological_process | 0.80 |
| Blood Cell Development | participates_in | biological_process | 0.70 |
| Gastrointestinal Motility | participates_in | biological_process | 0.70 |
| Airway Hydration | participates_in | biological_process | 0.70 |
| Nonalcoholic Fatty Liver Disease | associated_with | disease | 0.70 |
| Myocardial Development | participates_in | biological_process | 0.70 |
| Obesity | associated_with | disease | 0.70 |
| Chronic Kidney Disease | associated_with | disease | 0.70 |
| Hepatitis | activates | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| Inflammation | activates | disease | 0.65 |
| MTOR | activates | gene | 0.60 |
| TFEB | activates | gene | 0.60 |
| INFLAMMATION | activates | gene | 0.60 |
| Mtor | activates | pathway | 0.60 |
| HIF | activates | gene | 0.60 |
| GENES | activates | gene | 0.60 |
| benchmark_ot_ad_answer_key:ANT2 | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TFEB | activates | gene | 0.60 |
| benchmark_ot_ad_answer_key:ANT2 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||