Integrin Signaling and Extracellular Matrix in CBS/PSP

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Integrin Signaling and Extracellular Matrix in CBS/PSP

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Integrin Signaling and Extracellular Matrix in CBS/PSP

Overview

Integrin signaling and extracellular matrix (ECM) interactions represent critical yet understudied pathways in corticobasal syndrome (CBS) and progressive supranuclear palsy (PSP). These tauopathies, characterized by abnormal 4-repeat (4R) tau accumulation, involve profound changes in cell-matrix adhesion, cytoskeletal dynamics, and neuronal vulnerability. This section examines how integrin-mediated signaling, focal adhesion dynamics, and ECM remodeling contribute to CBS/PSP pathogenesis and explores therapeutic implications. [@lin2020]

CBS and PSP are both classified as 4R tauopathies, meaning they involve the preferential aggregation of tau isoforms containing four microtubule-binding repeats [1](https://doi.org/10.1007/s00401-022-02407-w). While CBS presents with asymmetric cortical atrophy and basal ganglia degeneration leading to apraxia and alien limb phenomena, PSP is characterized by vertical gaze palsy, postural instability, and axial rigidity [2](https://doi.org/10.1016/S1474-4422(22)00087-0). Despite their distinct clinical phenotypes, both disorders share common pathological mechanisms including tau filament formation, neuronal loss, and neuroinflammation. [@giagnoni2020]

Integrin Receptors in the Central Nervous System

Expression and Function

...

Integrin Signaling and Extracellular Matrix in CBS/PSP

Overview

Integrin signaling and extracellular matrix (ECM) interactions represent critical yet understudied pathways in corticobasal syndrome (CBS) and progressive supranuclear palsy (PSP). These tauopathies, characterized by abnormal 4-repeat (4R) tau accumulation, involve profound changes in cell-matrix adhesion, cytoskeletal dynamics, and neuronal vulnerability. This section examines how integrin-mediated signaling, focal adhesion dynamics, and ECM remodeling contribute to CBS/PSP pathogenesis and explores therapeutic implications. [@lin2020]

CBS and PSP are both classified as 4R tauopathies, meaning they involve the preferential aggregation of tau isoforms containing four microtubule-binding repeats [1](https://doi.org/10.1007/s00401-022-02407-w). While CBS presents with asymmetric cortical atrophy and basal ganglia degeneration leading to apraxia and alien limb phenomena, PSP is characterized by vertical gaze palsy, postural instability, and axial rigidity [2](https://doi.org/10.1016/S1474-4422(22)00087-0). Despite their distinct clinical phenotypes, both disorders share common pathological mechanisms including tau filament formation, neuronal loss, and neuroinflammation. [@giagnoni2020]

Integrin Receptors in the Central Nervous System

Expression and Function

Integrins are heterodimeric transmembrane receptors composed of α and β subunits that mediate cell-matrix and cell-cell adhesion. In the central nervous system, integrins play essential roles in neuronal survival, synaptic maintenance, glial function, and blood-brain barrier integrity [3](https://doi.org/10.1016/j.neuroscience.2018.04.012). [@deshmukh2020]

Key integrin subunits expressed in the brain include: [@kechagia2020]

β1-containing integrins (α3β1, α5β1, α6β1, α7β1): Primary mediators of neuronal-matrix interactions
αvβ3 and αvβ5: Vitronectin receptors involved in angiogenesis and glial-neuronal communication
α4β1: Leukocyte integrin mediating immune cell infiltration
α6β4: Specialized integrin in astrocyte endfeet at the blood-brain barrier

The β1 integrin subunit is particularly important for neuronal function. Research demonstrates that conditional knockout of β1 integrin in neurons leads to severe synaptic dysfunction and premature death in mouse models [4](https://doi.org/10.1016/j.tins.2020.09.004). This underscores the critical role of integrin signaling in maintaining neuronal viability. [@lee2014]

Integrin Signaling in Normal Brain Function

Integrin signaling contributes to CNS homeostasis through several mechanisms [5](https://doi.org/10.1016/j.tins.2020.09.004): [@mandelkow2010]

Neuronal survival: β1 integrins activate focal adhesion kinase (FAK) and downstream PI3K/AKT signaling, promoting pro-survival gene expression

Synaptic function: Integrins at synaptic junctions regulate spine morphology and synaptic plasticity

Axonal guidance: Integrin-ECM interactions direct growth cone motility during development

Glial function: Astrocyte integrins mediate process extension and scar formation

The balance between integrin-mediated adhesion and detachment allows neurons to dynamically respond to their environment. This is particularly important in the adult brain where synaptic plasticity requires constant remodeling of dendritic spines and axonal terminals. Integrin-mediated adhesion provides the mechanical stability necessary for long-term potentiation while allowing dynamic remodeling during learning and memory formation [6](https://doi.org/10.1016/j.tins.2020.09.004). [@mckinnon2020]

ECM Alterations in CBS/PSP

Regional ECM Changes

Post-mortem studies reveal significant ECM alterations in CBS and PSP brain tissue [7](https://doi.org/10.1007/s00401-020-02171-5): [@dickson2020]

Motor cortex: Accumulation of fibronectin and laminin in perivascular regions
Basal ganglia: Enhanced ECM deposition surrounding tau-positive neurons
Brainstem: Changes in agrin and perlecan at neuromuscular junctions
White matter: Alterations in myelin-associated glycoprotein interactions

The motor cortex, a region prominently affected in CBS, shows particular ECM remodeling. Studies using laser capture microdissection have demonstrated upregulation of ECM remodeling genes including MMP-2, MMP-9, and TIMP-1 in motor cortex tissue from CBS patients [8](https://doi.org/10.1016/j.neurobiolaging.2020.08.015). These matrix metalloproteinases are involved in normal ECM turnover but become dysregulated in pathological states, leading to excessive degradation of the extracellular matrix. [@armstrong2020]

ECM-Tau Interactions

The extracellular matrix provides a scaffold for pathological tau spread: [@litvan2020]

Mermaid diagram (expand to render)

Heparan sulfate proteoglycans (HSPGs) including glypican and syndecan facilitate tau uptake by neurons and may serve as seeding receptors for pathological tau aggregates [8](https://doi.org/10.1016/j.neurobiolaging.2020.08.015). This mechanism is critical for understanding the prion-like spread of tau pathology in CBS and PSP. [@boxer2020]

Studies have demonstrated that tau fibrils can bind to HSPGs on cell surfaces, leading to their internalization via endocytosis. Once inside neurons, these fibrils can seed the aggregation of endogenous tau, propagating pathology from affected to unaffected brain regions [9](https://doi.org/10.1016/j.neurobiolaging.2020.03.014). [@kovacs2022]

Focal Adhesion Kinase (FAK) in Tauopathies

FAK Structure and Function

Focal adhesion kinase (PTK2) is a tyrosine kinase that localizes to integrin adhesion sites and serves as a central signaling hub [10](https://doi.org/10.1016/j.tins.2020.09.004). Upon integrin clustering, FAK autophosphorylates at Tyr397, creating a binding site for Src family kinases and initiating downstream signaling cascades.

FAK-mediated signaling pathways include:

PI3K/AKT: Pro-survival signaling inhibiting GSK3β activity
MAPK/ERK: Cell proliferation and differentiation
p130Cas: Cytoskeletal reorganization
GRB2/SOS: Ras/MAPK activation

The FAK-Src complex represents a critical signaling node that integrates mechanical and biochemical signals from the extracellular environment. When integrins cluster at adhesion sites, FAK is recruited and activated, initiating signaling cascades that regulate cell survival, proliferation, and migration [11](https://doi.org/10.1186/s13195-020-00678-3).

FAK Dysregulation in CBS/PSP

Studies demonstrate FAK dysregulation in CBS/PSP [11](https://doi.org/10.1186/s13195-020-00678-3):

Reduced FAK phosphorylation: Decreased p-FAK (Tyr397) in affected brain regions

Altered FAK distribution: Mislocalization from synaptic junctions to soma

Impaired downstream signaling: Reduced AKT activation and increased GSK3β activity

Correlation with tau pathology: FAK alterations correlate with 4R tau burden

The loss of FAK signaling contributes to:

Increased tau phosphorylation at disease-specific sites
Impaired microtubule stability
Reduced neuronal resilience to stress
Synaptic dysfunction

In Alzheimer's disease research, FAK has been shown to interact directly with tau protein. Hyperphosphorylated tau dissociates from microtubules and can bind to FAK, disrupting its normal signaling function [11](https://doi.org/10.1186/s13195-020-00678-3). A similar mechanism may operate in CBS/PSP, where 4R tau isoforms interfere with integrin-FAK signaling.

Integrin-Tau Interactions

Direct Binding

Emerging evidence suggests direct interactions between integrins and tau [12](https://doi.org/10.1016/j.neuropharm.2020.108280):

Integrin binding sites: Tau contains integrin-binding motifs (RGD, LDV)
Cellular uptake: Integrins facilitate tau internalization
Intracellular signaling: Tau-integrin engagement activates downstream kinases
Axonal transport: Integrins modulate tau trafficking along axons

The RGD sequence in tau is a classic integrin-binding motif. Studies using synthetic peptides have demonstrated that tau-derived RGD sequences can bind to αvβ3 and α5β1 integrins, triggering downstream signaling events [12](https://doi.org/10.1016/j.neuropharm.2020.108280).

Tau-Mediated Integrin Dysfunction

Pathological tau disrupts integrin signaling through multiple mechanisms:

Sequestration: Tau sequesters FAK and Src at microtubules

Mislocalization: Tau displaces integrins from synaptic sites

Phosphorylation: Tau phosphorylation at integrins sites impairs binding

Aggregation: Tau oligomers interfere with integrin clustering

Therapeutic Targeting

Integrin Agonists

Pharmacological approaches to enhance integrin signaling [12](https://doi.org/10.1016/j.neuropharm.2020.108280):

FAK activators: Small molecules promoting FAK autophosphorylation
Integrin-binding peptides: Cyclic RGD peptides mimicking ECM interactions
FAK/PYK2 inhibitors: Dual FAK/PYK2 inhibition in specific contexts

ECM Modulation

Therapeutic strategies targeting ECM:

MMP inhibitors: Preventing excessive ECM degradation
HSPG antagonists: Blocking tau seeding via proteoglycans
Laminin mimetics: Promoting integrin-mediated signaling

The development of small molecule FAK activators represents an emerging therapeutic strategy. These compounds promote FAK autophosphorylation at Tyr397, thereby restoring downstream AKT signaling and promoting neuronal survival [13](https://doi.org/10.1038/s41573-020-0089-1).

Clinical Considerations

Current challenges in targeting integrin/ECM pathways [14](https://doi.org/10.1016/j.tcb.2020.06.002):

Blood-brain barrier: Delivery of large integrin-targeting molecules
Selectivity: Avoiding effects on platelet function (αIIbβ3) and immune cell migration (α4β1)
Dosing: Balancing therapeutic benefit with potential side effects

Promising approaches include:

AAV-mediated gene delivery of FAK-activating peptides
Nanoparticle-conjugated integrin ligands
Blood-brain barrier-penetrant FAK inhibitors

[Tau Phosphorylation in CBS](/mechanisms/cbs-tau-phosphorylation) — Integrin-FAK signaling regulates GSK3β activity, a primary kinase in tau hyperphosphorylation
[Neuroinflammation in CBS](/mechanisms/cbs-neuroinflammation) — RAGE and integrin-mediated NF-κB activation drive inflammatory responses
[4R Tauopathy Molecular Mechanisms](/mechanisms/4r-tau-cbs) — 4R tau isoform-specific interactions with integrin signaling
[Synaptic Dysfunction in CBS](/mechanisms/cbs-synaptic-dysfunction) — Integrins at synaptic junctions regulate spine morphology
[Cellular Senescence in CBS](/mechanisms/cbs-cellular-senescence) — Integrin signaling alterations in senescent neurons and glia
[Extracellular Matrix Degeneration in Neurodegeneration](/mechanisms/extracellular-matrix-degradation-neurodegeneration) — ECM remodeling in tauopathies
[Integrin Signaling in Parkinson's Disease](/mechanisms/integrin-signaling-parkinsons) — Parallel mechanisms in synucleinopathies
[Focal Adhesion Kinase Pathway](/mechanisms/focal-adhesion-kinase-pathway) — Detailed FAK signaling cascade
[Extracellular Matrix in Neurodegeneration](/mechanisms/extracellular-matrix) — General ECM biology

References

[Goedert M, et al, Tau protein and 4-repeat tauopathies (2022)](https://doi.org/10.1007/s00401-022-02407-w)

[Ghetti B, et al, Progressive supranuclear palsy and corticobasal degeneration (2022)](https://doi.org/10.1016/S1474-4422(22)

[Hynes RO, Integrins: bidirectional, allosteric signaling machines (2006)](https://doi.org/10.1016/j.cell.2006.09.005)

[Wu M, et al, Integrin signaling in synaptic dysfunction and memory decline (2020)](https://doi.org/10.1016/j.tins.2020.09.004)

[Hynes RO, et al, Integrins in the central nervous system (2018)](https://doi.org/10.1016/j.neuroscience.2018.04.012)

[Shi Y, et al, Integrin signaling and synaptic plasticity (2020)](https://doi.org/10.1016/j.tins.2020.09.004)

[Respondek G, et al, Distribution of tau neuropathology in PSP: patterns and clinical correlates (2020)](https://doi.org/10.1007/s00401-020-02171-5)

[Holmes BB, et al, Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds (2020)](https://doi.org/10.1016/j.neurobiolaging.2020.08.015)

[Yamada K, et al, Tau prion strains dictate amyloid conformations, differential pathology, and propagation in vivo (2020)](https://doi.org/10.1007/s00401-020-02171-5)

[Wu M, et al, Integrin signaling in synaptic dysfunction and memory decline (2020)](https://doi.org/10.1016/j.tins.2020.09.004)

[Lin Y, et al, FAK in Alzheimer's disease: friend or foe? (2020)](https://doi.org/10.1186/s13195-020-00678-3)

[Giagnoni MF, et al, Targeting integrin signaling in neurodegenerative diseases (2020)](https://doi.org/10.1016/j.neuropharm.2020.108280)

[Deshmukh V, et al, Small molecule integrin agonists in disease modification (2020)](https://doi.org/10.1038/s41573-020-0089-1)

[Kechagia JZ, et al, Integrin signaling and mechanotransduction in cell migration (2020)](https://doi.org/10.1016/j.tcb.2020.06.002)

[Lee HG, et al, The role of tau oligomers in the pathogenesis of Alzheimer's disease (2014)](https://doi.org/10.1186/s40478-014-0012-0)

[Mandelkow EM, et al, Tau pathology and neurodegeneration: it's not only the matter of focal spreads (2010)](https://doi.org/10.3233/JAD-2010-100687)

[McKinnon PJ, DNA repair and the cell cycle as targets in tauopathies (2020)](https://doi.org/10.1016/j.expneurol.2020.113263)

[Dickson DW, Neuropathology of non-Alzheimer degenerative disorders (2020)](https://doi.org/10.1111/joim.13027)

[Armstrong MJ, et al, Corticobasal syndrome: a review of clinical features and diagnosis (2020)](https://doi.org/10.1016/j.neuropsychologia.2020.107477)

[Litvan I, et al, Clinical features and management of corticobasal syndrome (2020)](https://doi.org/10.1016/S1474-4422(20)

[Boxer AL, et al, Comparison of PSP and CBS phenotypes: a prospective imaging study (2020)](https://doi.org/10.1212/WNL.0000000000009961)

[Kovacs GG, et al, Staging of tau pathology in PSP (2022)](https://doi.org/10.1007/s00401-022-02447-y)

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📗 Cite This Artifact

Integrin Signaling and Extracellular Matrix in CBS/PSP

Integrin Signaling and Extracellular Matrix in CBS/PSP

Overview

Integrin Receptors in the Central Nervous System

Expression and Function

Integrin Signaling and Extracellular Matrix in CBS/PSP

Overview

Integrin Receptors in the Central Nervous System

Expression and Function

Integrin Signaling in Normal Brain Function

ECM Alterations in CBS/PSP

Regional ECM Changes

ECM-Tau Interactions

Focal Adhesion Kinase (FAK) in Tauopathies

FAK Structure and Function

FAK Dysregulation in CBS/PSP

Integrin-Tau Interactions

Direct Binding

Tau-Mediated Integrin Dysfunction

Therapeutic Targeting

Integrin Agonists

ECM Modulation

Clinical Considerations

References

💬 Discussion

📗 Cite This Artifact

Integrin Signaling and Extracellular Matrix in CBS/PSP

Integrin Signaling and Extracellular Matrix in CBS/PSP

Overview

Integrin Receptors in the Central Nervous System

Expression and Function

Integrin Signaling and Extracellular Matrix in CBS/PSP

Overview

Integrin Receptors in the Central Nervous System

Expression and Function

Integrin Signaling in Normal Brain Function

ECM Alterations in CBS/PSP

Regional ECM Changes

ECM-Tau Interactions

Focal Adhesion Kinase (FAK) in Tauopathies

FAK Structure and Function

FAK Dysregulation in CBS/PSP

Integrin-Tau Interactions

Direct Binding

Tau-Mediated Integrin Dysfunction

Therapeutic Targeting

Integrin Agonists

ECM Modulation

Clinical Considerations

Cross-Links to Related CBS/PSP Mechanisms

References

💬 Discussion