ID: h-f0e5efbf54
Hypothesis
CDK5 Inhibition Blocks Activity-Dependent Tau Propagation
Neuronal activity induces CDK5-dependent tau phosphorylation and packaging into exosomes.
EvidencePending (0%)📖 0 cit🗣 1 debates✓ 3 support✗ 3 oppose
✓ All Quality Gates Passed
🧪 Overview
Neuronal activity induces CDK5-dependent tau phosphorylation and packaging into exosomes. Selective CDK5 inhibition prevents loading and reduces trans-synaptic tau spreading. Requires development of selective CDK5 inhibitors (not pan-CDK inhibitors like dinaciclib).
🧬 Mechanism
🔗 Mechanism from KG for CDK5
Auto-built from this analysis's top knowledge-graph edges.
graph TD
CDK5["CDK5"] -->|regulates| tau_packaging_into_exosom["tau packaging into exosomes"]
p25_CDK5_hyperactivity["p25/CDK5 hyperactivity"] -->|causes| tau_hyperphosphorylation["tau hyperphosphorylation"]
CDK5_1["CDK5"] -->|regulates| memory_consolidation["memory consolidation"]
style CDK5 fill:#4fc3f7,stroke:#333,color:#000
style tau_packaging_into_exosom fill:#4fc3f7,stroke:#333,color:#000
style p25_CDK5_hyperactivity fill:#4fc3f7,stroke:#333,color:#000
style tau_hyperphosphorylation fill:#4fc3f7,stroke:#333,color:#000
style CDK5_1 fill:#4fc3f7,stroke:#333,color:#000
style memory_consolidation fill:#4fc3f7,stroke:#333,color:#000⚖️ Evidence
⚖️ Evidence Matrix3 supports3 contradicts
Contradicts
CDK5 is essential for memory consolidation - chronic inhibition may impair cognition
📖 Linked Papers
No linked papers recorded for this hypothesis yet.
🏥 Translation
🧬 3D Protein Structure — CDK5
No curated PDB or AlphaFold mapping for CDK5 yet. Search RCSB →
💉 Clinical Trials
No clinical trials data linked to this hypothesis yet.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for CDK5.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.
🏆 Tournament
🏆 Arenas / Elo
No arena matches recorded yet. Browse Arenas →
📊 Market Indicators
7d Trend
↔
Stable
7d Momentum
▼ 0.5%
Volatility
Low
0.0018
Events (7d)
2
Price History
▼9.7%💾 Resource Usage
API Calls
1
Total Cost
$0.0000
▸Metadatasource: v1_phase_c_backfill · origin_type: debate_synthesizer
| source | v1_phase_c_backfill |
| origin_type | debate_synthesizer |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.