Purinergic-Metabolic Coupling Restoration

graph TD
    NAD__biosynthesis["NAD+ biosynthesis"] -->|activates| sirtuin_function["sirtuin function"]
    TREM2["TREM2"] -->|mediates| amyloid_clearance["amyloid clearance"]
    NAMPT["NAMPT"] -->|associated with| Nad__Biosynthesis["Nad+ Biosynthesis"]
    Nad__Biosynthesis_1["Nad+ Biosynthesis"] -->|associated with| sirtuin_function_2["sirtuin function"]
    apoe4["apoe4"] -->|causes| metabolic_crisis["metabolic crisis"]
    APOE4["APOE4"] -.->|inhibits| NAMPT_3["NAMPT"]
    APOE4_4["APOE4"] -->|activates| MTOR_signaling["MTOR signaling"]
    MTOR["MTOR"] -->|regulates| metabolic_flexibility["metabolic flexibility"]
    APOE4_5["APOE4"] -->|causes| lipid_droplet_formation["lipid droplet formation"]
    DGAT1["DGAT1"] -->|catalyzes| lipid_droplet_formation_6["lipid droplet formation"]
    APOE4_7["APOE4"] -->|disrupts| mitochondrial_ER_contacts["mitochondrial-ER contacts"]
    VDAC1["VDAC1"] -->|regulates| mitochondrial_ER_contacts_8["mitochondrial-ER contacts"]
    style NAD__biosynthesis fill:#81c784,stroke:#333,color:#000
    style sirtuin_function fill:#4fc3f7,stroke:#333,color:#000
    style TREM2 fill:#4fc3f7,stroke:#333,color:#000
    style amyloid_clearance fill:#4fc3f7,stroke:#333,color:#000
    style NAMPT fill:#ce93d8,stroke:#333,color:#000
    style Nad__Biosynthesis fill:#81c784,stroke:#333,color:#000
    style Nad__Biosynthesis_1 fill:#81c784,stroke:#333,color:#000
    style sirtuin_function_2 fill:#4fc3f7,stroke:#333,color:#000
    style apoe4 fill:#ef5350,stroke:#333,color:#000
    style metabolic_crisis fill:#4fc3f7,stroke:#333,color:#000
    style APOE4 fill:#ce93d8,stroke:#333,color:#000
    style NAMPT_3 fill:#ce93d8,stroke:#333,color:#000
    style APOE4_4 fill:#ce93d8,stroke:#333,color:#000
    style MTOR_signaling fill:#81c784,stroke:#333,color:#000
    style MTOR fill:#4fc3f7,stroke:#333,color:#000
    style metabolic_flexibility fill:#4fc3f7,stroke:#333,color:#000
    style APOE4_5 fill:#ce93d8,stroke:#333,color:#000
    style lipid_droplet_formation fill:#4fc3f7,stroke:#333,color:#000
    style DGAT1 fill:#4fc3f7,stroke:#333,color:#000
    style lipid_droplet_formation_6 fill:#4fc3f7,stroke:#333,color:#000
    style APOE4_7 fill:#ce93d8,stroke:#333,color:#000
    style mitochondrial_ER_contacts fill:#4fc3f7,stroke:#333,color:#000
    style VDAC1 fill:#4fc3f7,stroke:#333,color:#000
    style mitochondrial_ER_contacts_8 fill:#4fc3f7,stroke:#333,color:#000