concept

DGAT2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DGAT2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

98Connections

0Hypotheses

1Analyses

50Outgoing

40Incoming

0Experiments

1Debates

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💡 Concept Info

Name	DGAT2
Key Genes/Proteins	ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, Amyloid-Beta, AMYLOID-BETA, AND
Related Diseases	Aging, Als, ALS, Alzheimer, Alzheimer's disease
Related Pathways	Amyloid

Pathway Diagram

graph TD
    DGAT2["DGAT2"]
    DGAT2 -->|"inhibits"| Als["Als"]
    DGAT2 -->|"activates"| lipid_droplet_formation["lipid droplet formation"]
    DGAT2 -->|"expressed in"| microglia["microglia"]
    DGAT2 -->|"activates"| Ms["Ms"]
    DGAT2 -->|"activates"| Alzheimer["Alzheimer"]
    DGAT2 -->|"activates"| Infection["Infection"]
    DGAT2 -->|"activates"| Inflammation["Inflammation"]
    DGAT2 -->|"activates"| Senescence["Senescence"]
    DGAT2 -->|"activates"| Obesity["Obesity"]
    BMAL1["BMAL1"] -->|"activates"| DGAT2
    HDAC6["HDAC6"] -->|"activates"| DGAT2
    BAX["BAX"] -->|"inhibits"| DGAT2
    PLIN2["PLIN2"] -->|"activates"| DGAT2
    APOPTOSIS["APOPTOSIS"] -->|"inhibits"| DGAT2
    CYTC["CYTC"] -->|"inhibits"| DGAT2
    BCL_2["BCL-2"] -->|"inhibits"| DGAT2
    NEURODEGENERATION["NEURODEGENERATION"] -->|"activates"| DGAT2
    FOS["FOS"] -->|"activates"| DGAT2

Outgoing (58)

Target	Relation	Type	Str
lipid droplet	involved_in	process	0.95
triacylglycerol synthesis	associated_with	process	0.90
Lipid Droplet Formation	involved_in	process	0.90
triacylglycerol biosynthesis	regulates	process	0.90
Neurodegeneration	involved_in	process	0.85
endolysosomal lipid accumulation	suppresses	phenotype	0.85
neurodegeneration	protects_against	phenotype	0.80
tauopathy	therapeutic_target	disease	0.75
Als	inhibits	disease	0.75
lipid droplet formation	activates	process	0.70
Alzheimer's disease	associated_with	disease	0.70
microglia	expressed_in	cell_type	0.70
lipid droplet dynamics	regulates	phenotype	0.70
Als	activates	disease	0.65
Ms	activates	disease	0.65
Alzheimer	activates	disease	0.65
Infection	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Atherosclerosis	associated_with	disease	0.65
ALS	activates	disease	0.65
Aging	associated_with	disease	0.65
Inflammation	activates	disease	0.65
Cardiovascular	associated_with	disease	0.65
Senescence	activates	disease	0.65
Obesity	activates	disease	0.65
Anxiety	activates	disease	0.65
Amyloid-Beta	activates	protein	0.60
PCSK9	associated_with	gene	0.60
Cholesterol	inhibits	pathway	0.60
AUTOPHAGY	inhibits	gene	0.60
FOXO1	inhibits	gene	0.60
Autophagy	inhibits	pathway	0.60
Cholesterol	activates	pathway	0.60
Oxidative Stress	activates	pathway	0.60
Synaptic Plasticity	activates	pathway	0.60
Lipid Metabolism	regulates	pathway	0.60
Phagocytosis	activates	pathway	0.60
GENES	activates	gene	0.60
BIP	activates	gene	0.60
FAS	activates	gene	0.60
HDAC6	activates	gene	0.60
Amyloid	activates	pathway	0.60
Microglia	activates	cell_type	0.60
Neuron	inhibits	cell_type	0.60
OXIDATIVE STRESS	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
PHAGOCYTOSIS	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
MICROGLIA	activates	gene	0.60
AMYLOID	activates	gene	0.60

Incoming (40)

Source	Relation	Type	Str
BMAL1	activates	gene	0.90
DGAT1	activates	gene	0.70
ALZHEIMER'S DISEASE	activates	gene	0.60
MICROGLIA	activates	gene	0.60
AMYLOID	activates	gene	0.60
AMYLOID-BETA	activates	gene	0.60
DGAT1	inhibits	gene	0.60
AND	activates	gene	0.60
HDAC6	activates	gene	0.60
PLIN2	regulates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
FOS	activates	gene	0.60
STAT3	activates	gene	0.60
BDNF	activates	gene	0.60
MMP2	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
ARC	activates	gene	0.60
PTEN	activates	gene	0.60
ANXIETY	activates	gene	0.60
IL6	activates	gene	0.60
GENES	regulates	gene	0.60
MMP9	activates	gene	0.60
NGF	activates	gene	0.60
IGF1	activates	gene	0.60
FOXO1	inhibits	gene	0.60
APOC3	associated_with	gene	0.60
LDLR	associated_with	gene	0.60
BAX	inhibits	gene	0.60
PLIN2	activates	gene	0.60
APOPTOSIS	inhibits	gene	0.60
CYTC	inhibits	gene	0.60
BCL-2	inhibits	gene	0.60
GENES	activates	gene	0.60
PHAGOCYTOSIS	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
microglia	activates	cell_type	0.50
Alzheimer'S Disease	activates	disease	0.50
disease	activates	disease	0.50
ALZHEIMER'S	activates	concept	0.50
microglia	inhibits	cell_type	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Which specific metabolic pathways in APOE4+ microglia are most therapeutically t

neurodegeneration | 2026-04-08 | 7 hypotheses Top: 0.455

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

While APOE4 disrupts microglial metabolism broadly, the debate didn't identify w

closed · Rounds: 4 · Score: 0.92 · 2026-04-09

Related Research

Hypotheses and analyses mentioning DGAT2 in their description or question text

No additional research found