concept

DGAT2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DGAT2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

98Connections

0Hypotheses

0Analyses

50Outgoing

41Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	DGAT2
Key Genes/Proteins	BMAL1, DGAT1
Related Diseases	endolysosomal lipid accumulation, neurodegeneration, Als, tauopathy, Alzheimer's disease

Wiki Pages (6)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    DGAT2["DGAT2"]
    DGAT2 -->|"inhibits"| Als["Als"]
    DGAT2 -->|"activates"| lipid_droplet_formation["lipid droplet formation"]
    DGAT2 -->|"expressed in"| microglia["microglia"]
    DGAT2 -->|"activates"| Ms["Ms"]
    DGAT2 -->|"activates"| Alzheimer["Alzheimer"]
    DGAT2 -->|"activates"| Infection["Infection"]
    DGAT2 -->|"activates"| Inflammation["Inflammation"]
    DGAT2 -->|"activates"| Senescence["Senescence"]
    DGAT2 -->|"activates"| Obesity["Obesity"]
    BMAL1["BMAL1"] -->|"activates"| DGAT2
    HDAC6["HDAC6"] -->|"activates"| DGAT2
    BAX["BAX"] -->|"inhibits"| DGAT2
    PLIN2["PLIN2"] -->|"activates"| DGAT2
    APOPTOSIS["APOPTOSIS"] -->|"inhibits"| DGAT2
    CYTC["CYTC"] -->|"inhibits"| DGAT2
    BCL_2["BCL-2"] -->|"inhibits"| DGAT2
    NEURODEGENERATION["NEURODEGENERATION"] -->|"activates"| DGAT2
    FOS["FOS"] -->|"activates"| DGAT2

Outgoing (57)

Target	Relation	Type	Str
lipid droplet	involved_in	process	0.95
triacylglycerol synthesis	associated_with	process	0.90
triacylglycerol biosynthesis	regulates	process	0.90
Lipid Droplet Formation	involved_in	process	0.90
endolysosomal lipid accumulation	suppresses	phenotype	0.85
Neurodegeneration	involved_in	process	0.85
neurodegeneration	protects_against	phenotype	0.80
Als	inhibits	disease	0.75
tauopathy	therapeutic_target	disease	0.75
lipid droplet formation	activates	process	0.70
Alzheimer's disease	associated_with	disease	0.70
microglia	expressed_in	cell_type	0.70
Aging	associated_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Ms	activates	disease	0.65
Alzheimer	activates	disease	0.65
Als	activates	disease	0.65
Infection	activates	disease	0.65
Inflammation	activates	disease	0.65
Senescence	activates	disease	0.65
Obesity	activates	disease	0.65
Anxiety	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
ALS	activates	disease	0.65
PCSK9	associated_with	gene	0.60
Cholesterol	inhibits	pathway	0.60
AUTOPHAGY	inhibits	gene	0.60
FOXO1	inhibits	gene	0.60
Autophagy	inhibits	pathway	0.60
Cholesterol	activates	pathway	0.60
GENES	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
PHAGOCYTOSIS	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
MICROGLIA	activates	gene	0.60
AMYLOID	activates	gene	0.60
Phagocytosis	activates	pathway	0.60
Apoptosis	inhibits	pathway	0.60
OXIDATIVE STRESS	activates	gene	0.60
BIP	activates	gene	0.60
FAS	activates	gene	0.60
Oxidative Stress	activates	pathway	0.60
Synaptic Plasticity	activates	pathway	0.60
Lipid Metabolism	regulates	pathway	0.60
HDAC6	activates	gene	0.60
AND	activates	gene	0.60
Amyloid	activates	pathway	0.60
Microglia	activates	cell_type	0.60
Neuron	inhibits	cell_type	0.60

Incoming (41)

Source	Relation	Type	Str
BMAL1	activates	gene	0.90
DGAT1	activates	gene	0.70
APOC3	associated_with	gene	0.60
LDLR	associated_with	gene	0.60
HDAC6	activates	gene	0.60
BAX	inhibits	gene	0.60
PLIN2	activates	gene	0.60
APOPTOSIS	inhibits	gene	0.60
CYTC	inhibits	gene	0.60
BCL-2	inhibits	gene	0.60
PLIN2	regulates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
FOS	activates	gene	0.60
STAT3	activates	gene	0.60
BDNF	activates	gene	0.60
MMP2	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
ARC	activates	gene	0.60
PTEN	activates	gene	0.60
ANXIETY	activates	gene	0.60
IL6	activates	gene	0.60
GENES	regulates	gene	0.60
MMP9	activates	gene	0.60
NGF	activates	gene	0.60
IGF1	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
AND	activates	gene	0.60
MICROGLIA	activates	gene	0.60
AND	inhibits	gene	0.60
FOXO1	inhibits	gene	0.60
AMYLOID	activates	gene	0.60
GENES	activates	gene	0.60
PHAGOCYTOSIS	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
AMYLOID-BETA	activates	gene	0.60
DGAT1	inhibits	gene	0.60
microglia	activates	cell_type	0.50
Alzheimer'S Disease	activates	disease	0.50
disease	activates	disease	0.50
ALZHEIMER'S	activates	concept	0.50
microglia	inhibits	cell_type	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

DGAT2

Understanding Entity Pages

Wiki Pages (6)

Alzheimer's Disease

Microglia and neuroinflammation in Alzheimer's Disease

Lipid Droplet-Lysosome Axis Therapeutic Testing in Parkinson's Disease

DGAT1 — Diacylglycerol O-Acyltransferase 1