concept

MTOR SIGNALING

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MTOR SIGNALING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

379Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	MTOR SIGNALING
Key Genes/Proteins	PI3K, AKT, TBK1, STING, ACSL4
Related Diseases	GLYCOLYSIS, EPITHELIAL-MESENCHYMAL TRANSITION, CANCER

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    MTOR_SIGNALING["MTOR SIGNALING"]
    MTOR_SIGNALING -->|"involved_in"| Ovarian_Aging["Ovarian Aging"]
    MTOR_SIGNALING -->|"regulates"| PI3K["PI3K"]
    MTOR_SIGNALING -->|"involved_in"| Maternal_Microbiome_Effects_on["Maternal Microbiome Effects on Stem Cells"]
    MTOR_SIGNALING -->|"regulates"| Motor_Function["Motor Function"]
    MTOR_SIGNALING -->|"upregulates"| Dendritic_Spine_Density["Dendritic Spine Density"]
    MTOR_SIGNALING -.protects against.-> Neurodegeneration["Neurodegeneration"]
    MTOR_SIGNALING -->|"modulates"| Synaptic_Function["Synaptic Function"]
    TSC2["TSC2"] -->|"inhibits"| MTOR_SIGNALING
    mTORC1["mTORC1"] -->|"activates"| MTOR_SIGNALING
    AKT["AKT"] -->|"regulates"| MTOR_SIGNALING
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| MTOR_SIGNALING
    RB1CC1_knockdown["RB1CC1 knockdown"] -->|"inhibits"| MTOR_SIGNALING
    Paeoniflorin["Paeoniflorin"] -->|"downregulates"| MTOR_SIGNALING
    Sandhoff_Disease["Sandhoff Disease"] -->|"downregulates"| MTOR_SIGNALING

Outgoing (129)

Target	Relation	Type	Str
PI3K	regulates	gene	0.95
PI3K	activates	gene	0.95
PI3K	therapeutic_target	gene	0.65
STEM CELLS	regulates	cell_type	0.65
TBK1	targets	gene	0.65
STING	targets	gene	0.65
ACSL4	targets	gene	0.65
GLYCOLYSIS	regulates	phenotype	0.65
EPITHELIAL-MESENCHYMAL TRANSITION	treats	phenotype	0.65
JNK	stabilizes	gene	0.60
OXIDATIVE STRESS	activates	process	0.50
NEURODEGENERATION	regulates	process	0.50
PI3K	causes	gene	0.50
PI3K	inhibits	gene	0.50
HEPATOCYTES	activates	concept	0.50
CURCUMIN	activates	concept	0.50
DENTATE GYRUS	associated_with	brain_region	0.50
TFEB	associated_with	gene	0.50
APOE	associated_with	gene	0.50
LDLR	associated_with	gene	0.50
SYK	associated_with	gene	0.50
T CELLS	associated_with	cell_type	0.50
FIBROBLASTS	associated_with	cell_type	0.50
PDGF	associated_with	gene	0.50
SIRT1	associated_with	gene	0.50
TP53	regulates	gene	0.45
NEUROINFLAMMATION	inhibits	disease	0.45
CURCUMIN	associated_with	drug	0.45
RAPAMYCIN	associated_with	drug	0.45
METFORMIN	associated_with	drug	0.45
FERROPTOSIS	associated_with	phenotype	0.45
AKT	associated_with	gene	0.45
APOPTOSIS	associated_with	phenotype	0.45
BCL2	associated_with	gene	0.45
BAX	associated_with	gene	0.45
TSC2	associated_with	gene	0.45
BREAST CANCER	associated_with	disease	0.45
OBESITY	associated_with	disease	0.45
STEM CELLS	associated_with	cell_type	0.45
INFLAMMATION	associated_with	phenotype	0.45
AUTOPHAGY	associated_with	phenotype	0.45
STROKE	associated_with	disease	0.45
HEPATOCYTES	associated_with	cell_type	0.45
MAPK	associated_with	gene	0.45
FIBROSIS	associated_with	disease	0.45
SNAP25	associated_with	gene	0.45
CELL DEATH	associated_with	phenotype	0.45
NEURONS	associated_with	cell_type	0.45
STRIATUM	associated_with	brain_region	0.45
MACROPHAGE	associated_with	cell_type	0.45

Incoming (250)

Source	Relation	Type	Str
AKT	regulates	gene	0.95
AUTOPHAGY	activates	process	0.95
AKT	activates	gene	0.95
AKT	therapeutic_target	gene	0.65
AKT	inhibits	gene	0.65
CANCER	activates	disease	0.65
MTOR	inhibits	gene	0.65
APOPTOSIS	activates	process	0.65
AUTOPHAGY	treats	phenotype	0.65
BAICALEIN	inhibits	drug	0.65
TREM2	inhibits	gene	0.65
AMPK	activates	gene	0.50
FERROPTOSIS	activates	process	0.50
AKT	causes	gene	0.50
AUTOPHAGY	regulates	process	0.50
AGING	regulates	process	0.50
MTOR	activates	gene	0.50
CELL PROLIFERATION	activates	process	0.50
Pi3K	associated_with	pathway	0.50
mTOR	associated_with	entity	0.50
cancer	associated_with	disease	0.50
Prostate Cancer	associated_with	disease	0.50
PSAP	associated_with	gene	0.50
late	interacts_with	disease	0.50
mTOR	interacts_with	entity	0.50
Endocytosis	interacts_with	pathway	0.50
SYNAPSE	interacts_with	concept	0.50
cardiomyopathy	inhibits	disease	0.50
mTOR	inhibits	entity	0.50
ferroptosis	inhibits	phenotype	0.50
Microrna	inhibits	pathway	0.50
Autophagy	activates	process	0.50
mTOR	activates	entity	0.50
KEAP1	associated_with	gene	0.50
NRF2	associated_with	gene	0.50
CUL3	associated_with	gene	0.50
Dna Methylation	associated_with	pathway	0.50
Pi3K	activates	pathway	0.50
Pi3K/Akt	activates	pathway	0.50
PI3K/AKT/mTOR	activates	pathway	0.50
cancer	inhibits	disease	0.50
Epithelial-Mesenchymal Transition	activates	process	0.50
ferroptosis	activates	phenotype	0.50
PTEN	activates	gene	0.50
cancer	activates	disease	0.50
SCD1	activates	gene	0.50
SREBP1	activates	protein	0.50
oxidative stress	activates	phenotype	0.50
MTORC1	activates	concept	0.50
mTOR	regulates	entity	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

MTOR SIGNALING

Understanding Entity Pages

Wiki Pages (20)

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

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Circadian Rhythm in Neurodegeneration

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Wnt Non-Canonical Signaling Pathways in Neurodegeneration

Rapamycin ALS Trial - mTOR Inhibition for Amyotrophic Lateral Sclerosis

nf1-protein

Insulin Signaling in Parkinson's Disease

PEN2 Gene

IGF-1 Signaling Pathway in Neurodegeneration

Astrocytes

Thyroid Hormone Signaling Pathway in Neurodegeneration

Autophagy-Lysosomal Impairment Across Neurodegenerative Diseases

rapamycin-tauopathy

NF-κB Signaling Pathway in Neurodegeneration

Autophagy-Lysosomal Impairment Comparison — AD/PD/ALS/FTD/HD