🧫
Validate Mitochondria-Lysosome Contact Site Dysfunction in PD
experiment
Created: 2026-04-02T17:01:41
By: crosslink-v2
Quality:
67%
✓ SciDEX
ID: experiment-exp-wiki-experiments-mcs-pd-v
🧫 Experiment Protocol
Validation
Metadata
| experiment_type | validation |
| source | {'type': 'manual', 'source_name': 'wiki', 'extraction_date': '2026-04-16T01:00:16.901190Z', 'extracted_by': 'backfill_v1'} |
| entities | {'genes': ['GBA'], 'diseases': ["Parkinson's Disease"]} |
| model_system | human |
| summary | # Validate Mitochondria-Lysosome Contact Site Dysfunction in PD ## Background and Rationale Mitochondria-lysosome contact sites (MCS) represent critical subcellular structures that facilitate organell |
| replication_status | single_study |
| methodology_notes | Phase 1 (Days 1-14): Generate iPSC-derived dopaminergic neurons from GBA-PD patients (n=6 lines) and controls (n=6 lines) using established protocols. Culture cells for 35 days to achieve mature neuro |
| primary_outcome | Validate Validate Mitochondria-Lysosome Contact Site Dysfunction in PD |
| extraction_metadata | {'extraction_confidence': 0.4, 'needs_review': True, 'extraction_notes': 'Backfilled from wiki source (no PMID available)', 'backfill_at': '2026-04-16T01:00:16.901195'} |
🌍 Provenance Graph
9 nodes, 30 edges
derives from (16)
...and 11 more
Linked Artifacts (1381)