gene 3,783 words KG: GBA
Contents

GBA Gene

🧬 Gene Info
Gene SymbolGBA
Functionis a critical gene in the intersection of lysosomal storage disorders and neurodegenerative diseases.
Molecular Weight60 kDa
Amino Acids536 aa
PathwaysAmyloid, Autophagy, Autophagy-Lysosomal Pathway, Chaperone, Epigenetic
Ensembl IDENSG00000177628
GeneCardsGBA
Human Protein AtlasGBA
Associated DiseasesAD, ALI, ALS, Aging, Alzheimer
InteractionsFUNDC1, AMBRA1, PINK1, BCL2L13, NLRP3, ABCD3
KG Connections1489 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (23)

Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.65
APOE-Dependent Autophagy Restoration
Score: 0.61
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Smartphone-Detected Motor Variability Correction
Score: 0.56
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56

Related Analyses (12)

Does TFEB activation directly restore mutant GBA enzyme acti
molecular biology · failed
What is the therapeutic window between GCS inhibition effica
neurodegeneration · failed
GBA-Synuclein Loop: Therapeutic Strategies for Parkinson's D
neurodegeneration · completed
GBA-Synuclein Loop Therapeutics for PD
neurodegeneration · completed
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived

Related Experiments (12)

Autophagy Enhancement Drug Screening for Neurodegeneration
clinical · proposed · Score: 0.46
Genetic Risk Modifiers in DLB Phenotype
clinical · proposed · Score: 0.46
DNA Damage Repair Deficiency Validation Study in Parkinson's
clinical · proposed · Score: 0.46
LRRK2/GBA Mutation Carrier Resilience — Why Some Carriers Ne
validation · proposed · Score: 0.46
Validate Mitochondria-Lysosome Contact Site Dysfunction in P
validation · proposed · Score: 0.46

See Also (6)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed
AKT1 Gene
gene · KG edge: therapeutic_target
ADAM10 — A Disintegrin And Metalloproteinase Domain 10
gene · KG edge: associated_with
ABCD3 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

GBA interacts_with FUNDC1
GBA interacts_with AMBRA1
GBA interacts_with PINK1
GBA interacts_with BCL2L13
GBA interacts_with NLRP3
GBA interacts_with ABCD3
GBA interacts_with FIP200
GBA interacts_with RTN3
GBA interacts_with SESN2
GBA associated_with PLIN2