Exercise-BDNF-Mitophagy Biomarker Study in PD

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Exercise-BDNF-Mitophagy Biomarker Study in PD

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experiment Created: 2026-04-02T10:01:41 By: crosslink-v2 Quality: 67% ✓ SciDEX ID: experiment-exp-wiki-experiments-exercise

🧫 Experiment Protocol Clinicalproposed

SUMMARY

# Exercise-BDNF-Mitophagy Biomarker Study in PD ## Background and Rationale Parkinson's disease (PD) is characterized by progressive neurodegeneration involving mitochondrial dysfunction and impaired cellular clearance mechanisms. Brain-derived neurotrophic factor (BDNF) plays a crucial role in neuronal survival, synaptic plasticity, and mitochondrial biogenesis. Exercise interventions have shown promise in PD management, potentially through BDNF-mediated enhancement of mitochondrial quality con

METHODOLOGY NOTES

Phase 1 (Weeks -2 to 0): Recruit 80 early-stage PD patients (Hoehn-Yahr stages 1-2), obtain informed consent, and complete baseline assessments including UPDRS-III, cognitive testing, and blood/CSF sampling. Phase 2 (Week 0): Randomize participants to moderate-intensity aerobic exercise (n=40) or standard care control (n=40). Exercise group performs supervised treadmill/cycling sessions 3x/week, 45 minutes at 60-70% HRmax. Phase 3 (Weeks 1-12): Continue interventions with weekly monitoring. Collect blood samples at weeks 4, 8, and 12 for BDNF ELISA, mitochondrial respiration analysis using Seahorse XF analyzer, and Western blotting for PINK1, Parkin, LC3-II/I, and VDAC1. Perform CSF sampling at week 6 and 12. Phase 4 (Weeks 8-16): Conduct mid-point and final clinical assessments including UPDRS-III, 6-minute walk test, and quality of life measures. Phase 5 (Weeks 12-14): Complete final biomarker collection and perform comprehensive proteomics analysis of mitochondrial and autophagy pro

▸Metadatasource: {'type': 'manual', 'source_name': 'wiki'

source	{'type': 'manual', 'source_name': 'wiki', 'extracted_by': 'backfill_v1', 'extraction_date': '2026-04-16T01:00:16.898799Z'}
summary	# Exercise-BDNF-Mitophagy Biomarker Study in PD ## Background and Rationale Parkinson's disease (PD) is characterized by progressive neurodegeneration involving mitochondrial dysfunction and impaired
entities	{'genes': ['BDNF'], 'diseases': ["Parkinson's Disease"]}
model_system	human
_schema_version	1
experiment_type	clinical
primary_outcome	Validate Exercise-BDNF-Mitophagy Biomarker Study in PD
methodology_notes	Phase 1 (Weeks -2 to 0): Recruit 80 early-stage PD patients (Hoehn-Yahr stages 1-2), obtain informed consent, and complete baseline assessments including UPDRS-III, cognitive testing, and blood/CSF sa
replication_status	single_study
extraction_metadata	{'backfill_at': '2026-04-16T01:00:16.898806', 'needs_review': True, 'extraction_notes': 'Backfilled from wiki source (no PMID available)', 'extraction_confidence': 0.4}

📊 Evidence Profile Foundational

Evidence Balance

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Certainty

100%

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0

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718

Outgoing

663

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Exercise-BDNF-Mitophagy Biomarker Study in PD

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