Complement Cascade as Final Common Effector

flowchart TD
    A["Spinal Cord Myelopathy Trigger<br/>ALS Trauma Autoimmune Ischemia"]
    B["Complement Activation<br/>Classical Lectin Alternative Pathway"]
    C["C3 Convertase Formation<br/>C3b Opsonization of Cord Tissue"]
    D["C5 Cleavage<br/>C5a Anaphylatoxin Released"]
    E["C5aR1 C5AR1 Signaling<br/>Spinal Microglia Myeloid Cells"]
    F["Uniform Inflammatory Milieu<br/>Common Downstream Effector Activated"]
    G["Standardized Neuroinflammation Pattern<br/>Convergent Spinal Cord Pathology"]
    H["C5aR1 Antagonist Treatment<br/>Avacopan PMX53"]
    I["Unified Therapeutic Strategy<br/>Across Diverse Myelopathy Triggers"]
    A --> B
    B --> C
    C --> D
    D --> E
    E --> F
    F --> G
    H -.->|"blocks convergent effector"| E
    H --> I
    style E fill:#7b1fa2,stroke:#ce93d8,color:#ce93d8
    style I fill:#1b5e20,stroke:#a5d6a7,color:#a5d6a7