NR1H3

Understanding Entity Pages

This page aggregates everything SciDEX knows about NR1H3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

Comprehensive gene page for NR1H3 (LXRA), a nuclear receptor regulating cholesterol homeostasis, lipid metabolism, and neuroinflammation in Alzheimer's and Parkinson's disease

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flowchart TD
    NR1H3["NR1H3<br/>(LXRalpha)"]
    
    %% Lipid metabolism pathway
    NR1H3 --|"expressed_in"|--> CHOL["Cholesterol<br/>Homeostasis"]
    NR1H3 --|"expressed_in"|--> LIPID["Lipid<br/>Metabolism"]
    NR1H3 --|"interacts_with"|--> SREBF2["SREBF2<br/>(SREBP-2)"]
    NR1H3 --|"interacts_with"|--> PPARA["PPARalpha<br/>(Fatty Acid Oxidation)"]
    
    %% Autophagy and cellular clearance
    NR1H3 --|"interacts_with"|--> AUTOPHAGY["Autophagy<br/>Pathway"]
    NR1H3 --|"interacts_with"|--> BECN1["BECLIN1<br/>(Autophagy Initiation)"]
    NR1H3 --|"interacts_with"|--> ULK1["ULK1<br/>(Autophagy Induction)"]
    NR1H3 --|"interacts_with"|--> LAMP2["LAMP2<br/>(Lysosomal Function)"]
    
    %% mTOR signaling
    NR1H3 --|"interacts_with"|--> MTOR["mTOR<br/>(Growth Regulation)"]
    NR1H3 --|"interacts_with"|--> RPTOR["RAPTOR<br/>(mTORC1 Component)"]
    
    %% Oxidative stress and cell death
    NR1H3 --|"interacts_with"|--> NFE2L2["NRF2<br/>(Antioxidant Response)"]
    NR1H3 --|"interacts_with"|--> TP53["p53<br/>(Tumor Suppressor)"]
    NR1H3 --|"interacts_with"|--> MAP3K5["ASK1<br/>(Stress Kinase)"]
    
    %% Phagocytosis and inflammation
    NR1H3 --|"interacts_with"|--> PHAGO["Phagocytosis<br/>Pathway"]
    NR1H3 --|"interacts_with"|--> C1Q["C1Q<br/>(Complement System)"]
    
    %% Disease outcomes
    AUTOPHAGY --|"dysfunction"|--> NEURODEGENERATION["Neurodegeneration<br/>Risk"]
    CHOL --|"dysregulation"|--> NEURODEGENERATION
    NFE2L2 --|"protection"|--> NEUROPROTECTION["Neuroprotection"]
    
    style NR1H3 fill:#006494
    style NEUROPROTECTION fill:#1b5e20
    style NFE2L2 fill:#1b5e20
    style AUTOPHAGY fill:#1b5e20
    style NEURODEGENERATION fill:#ef5350
    style TP53 fill:#4a1a6b
    style MTOR fill:#4a1a6b
    style CHOL fill:#5d4400
    style LIPID fill:#5d4400