gene

SIGLEC9

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SIGLEC9: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

44Connections
0Hypotheses
0Analyses
29Outgoing
15Incoming

Summary

Page for SIGLEC9 — Sialic Acid Binding Ig-Like Lectin 9

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🧬 Gene Info
Gene SymbolSIGLEC9
Full NameSialic Acid Binding Ig-Like Lectin 9
Chromosome19q13.4
Functionis a member of the CD33-related Siglec family of inhibitory lectins.
Primary ExpressionNeutrophils, monocytes, NK cells, B cells
Molecular Weight~55 kDa
Amino Acids482 aa
Exons11
UniProt IDQ9Y736
NCBI Gene ID27180
GeneCardsSIGLEC9
Human Protein AtlasSIGLEC9
FeatureValue
Genomic Coordinateschr19:50,761,328-50,778,310 (GRCh38)
Exon Count11
Associated DiseasesALS, Alzheimer's disease, Parkinson's disease, Tumor
InteractionsSIRPA, TPP1, VEGFB, C1R, C1S, CLN5
KG Connections44 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: SIGLEC9 — AlphaFold Q9Y736 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (9)

Knowledge base pages for this entity

Canonical Page

SIGLEC9 — Sialic Acid Binding Ig-Like Lectin 9

gene · 2748 words

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

therapeutic · 15794 words

SIGLEC10 — Sialic Acid Binding Ig-Like Lectin 10

gene · 2514 words

SIGLEC9 Protein

protein · 2432 words

TMEM106B

protein · 1600 words

ADAM15 Gene

gene · 795 words

Pathway Diagram

graph TD
    SIGLEC9["<b>SIGLEC9</b>"]
    Alzheimer{"Alzheimer"}
    SIGLEC9 -->|"therapeutic target"| Alzheimer
    Ms{"Ms"}
    SIGLEC9 -->|"therapeutic target"| Ms
    Dementia{"Dementia"}
    SIGLEC9 -->|"therapeutic target"| Dementia
    Als{"Als"}
    SIGLEC9 -->|"therapeutic target"| Als
    Tumor{"Tumor"}
    SIGLEC9 -->|"associated with"| Tumor
    Glioblastoma{"Glioblastoma"}
    SIGLEC9 -->|"therapeutic target"| Glioblastoma
    SIRPA["SIRPA"]
    SIGLEC9 -->|"associated with"| SIRPA
    GRN["GRN"]
    SIGLEC9 -->|"associated with"| GRN
    GBM["GBM"]
    SIGLEC9 -->|"therapeutic target"| GBM
    neurodegeneration["neurodegeneration"]
    SIGLEC9 -->|"implicated in"| neurodegeneration
    TREM2["TREM2"]
    TREM2 -->|"associated with"| SIGLEC9
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"therapeutic target"| SIGLEC9
    CTSH["CTSH"]
    CTSH -->|"associated with"| SIGLEC9
    TMEM106B["TMEM106B"]
    TMEM106B -->|"associated with"| SIGLEC9
    CD4["CD4"]
    CD4 -->|"therapeutic target"| SIGLEC9
    style SIGLEC9 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (29)

TargetRelationTypeStr
oxidative stress responseparticipates_inpathway0.70
Alzheimertherapeutic_targetdisease0.65
Mstherapeutic_targetdisease0.65
Dementiatherapeutic_targetdisease0.65
Alstherapeutic_targetdisease0.65

Incoming (15)

SourceRelationTypeStr
TREM2associated_withgene0.60
CTSHassociated_withgene0.60
TMEM106Bassociated_withgene0.60
CD4therapeutic_targetgene0.60
C1Rinteracts_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found