Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SIGLEC9: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | SIGLEC9 |
| Full Name | Sialic Acid Binding Ig-Like Lectin 9 |
| Chromosome | 19q13.4 |
| Function | is a member of the CD33-related Siglec family of inhibitory lectins. |
| Primary Expression | Neutrophils, monocytes, NK cells, B cells |
| Molecular Weight | ~55 kDa |
| Amino Acids | 482 aa |
| Exons | 11 |
| UniProt ID | Q9Y736 |
| NCBI Gene ID | 27180 |
| GeneCards | SIGLEC9 |
| Human Protein Atlas | SIGLEC9 |
| Feature | Value |
| Genomic Coordinates | chr19:50,761,328-50,778,310 (GRCh38) |
| Exon Count | 11 |
| Associated Diseases | ALS, Alzheimer's disease, Parkinson's disease, Tumor |
| Interactions | SIRPA, TPP1, VEGFB, C1R, C1S, CLN5 |
| KG Connections | 44 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
SIGLEC9["<b>SIGLEC9</b>"]
Alzheimer{"Alzheimer"}
SIGLEC9 -->|"therapeutic target"| Alzheimer
Ms{"Ms"}
SIGLEC9 -->|"therapeutic target"| Ms
Dementia{"Dementia"}
SIGLEC9 -->|"therapeutic target"| Dementia
Als{"Als"}
SIGLEC9 -->|"therapeutic target"| Als
Tumor{"Tumor"}
SIGLEC9 -->|"associated with"| Tumor
Glioblastoma{"Glioblastoma"}
SIGLEC9 -->|"therapeutic target"| Glioblastoma
SIRPA["SIRPA"]
SIGLEC9 -->|"associated with"| SIRPA
GRN["GRN"]
SIGLEC9 -->|"associated with"| GRN
GBM["GBM"]
SIGLEC9 -->|"therapeutic target"| GBM
neurodegeneration["neurodegeneration"]
SIGLEC9 -->|"implicated in"| neurodegeneration
TREM2["TREM2"]
TREM2 -->|"associated with"| SIGLEC9
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
ALZHEIMER_S_DISEASE -->|"therapeutic target"| SIGLEC9
CTSH["CTSH"]
CTSH -->|"associated with"| SIGLEC9
TMEM106B["TMEM106B"]
TMEM106B -->|"associated with"| SIGLEC9
CD4["CD4"]
CD4 -->|"therapeutic target"| SIGLEC9
style SIGLEC9 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| oxidative stress response | participates_in | pathway | 0.70 |
| Alzheimer | therapeutic_target | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| Dementia | therapeutic_target | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Tumor | associated_with | disease | 0.65 |
| Glioblastoma | therapeutic_target | disease | 0.65 |
| SIRPA | associated_with | gene | 0.60 |
| GRN | associated_with | gene | 0.60 |
| GBM | therapeutic_target | gene | 0.60 |
| TMEM106B | associated_with | gene | 0.60 |
| CTSH | associated_with | gene | 0.60 |
| SIRPA | interacts_with | gene | 0.60 |
| TPP1 | interacts_with | gene | 0.60 |
| VEGFB | interacts_with | gene | 0.60 |
| DEMENTIA | therapeutic_target | gene | 0.60 |
| ALZHEIMER | therapeutic_target | gene | 0.60 |
| ALZHEIMER'S DISEASE | therapeutic_target | gene | 0.60 |
| Alzheimer's disease | interacts_with | disease | 0.60 |
| Parkinson's disease | interacts_with | disease | 0.60 |
| ALS | interacts_with | disease | 0.60 |
| multiple sclerosis | interacts_with | disease | 0.60 |
| blood-brain barrier | participates_in | pathway | 0.60 |
| astrocytes | expressed_in | cell_type | 0.60 |
| oligodendrocytes | expressed_in | cell_type | 0.60 |
| microglia | expressed_in | cell_type | 0.60 |
| Alzheimer's disease | causes | disease | 0.60 |
| Parkinson's disease | causes | disease | 0.60 |
| ALS | causes | disease | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TREM2 | associated_with | gene | 0.60 |
| CTSH | associated_with | gene | 0.60 |
| TMEM106B | associated_with | gene | 0.60 |
| CD4 | therapeutic_target | gene | 0.60 |
| C1R | interacts_with | gene | 0.60 |
| C1S | interacts_with | gene | 0.60 |
| CLN5 | interacts_with | gene | 0.60 |
| CR1 | interacts_with | gene | 0.60 |
| PARP1 | interacts_with | gene | 0.60 |
| ADAM15 | causes | gene | 0.60 |
| CD33 | causes | gene | 0.60 |
| CD38 | causes | gene | 0.60 |
| GPNMB | causes | gene | 0.60 |
| GRN | causes | gene | 0.60 |
| ALZHEIMER'S DISEASE | therapeutic_target | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||