gene

CNR2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CNR2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

52Connections

0Hypotheses

0Analyses

30Outgoing

22Incoming

1Experiments

No summary available yet. View on Wiki →

🧬 Gene Info

Gene Symbol	CNR2
Full Name	Cannabinoid Receptor Type 2
Chromosome	1p36.12
Function	is a component of the endocannabinoid system, a neuromodulatory system involved in various physiological processes including pain sensation, immune response, and neuroinflammation.
Primary Expression	immune cells and peripheral tissues
Molecular Weight	~40 kDa
Amino Acids	360 aa
Pathways	MAPK pathway, PI3K
UniProt ID	P47972
NCBI Gene ID	1269
Ensembl ID	ENSG00000188322
OMIM	605026
GeneCards	CNR2
Human Protein Atlas	CNR2
Alternative Names	CB2, CNR2, CX5, GPR18, CB2R
Associated Diseases	ALS, Alzheimer
Interactions	CCR5, CXCL8, C3AR1, GRM2, CXCL12, MTNR1A
KG Connections	52 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CNR2 — AlphaFold P47972 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (9)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CNR2["<b>CNR2</b>"]
    Alzheimer{"Alzheimer"}
    CNR2 -->|"activates"| Alzheimer
    Dementia{"Dementia"}
    CNR2 -->|"activates"| Dementia
    Neuroinflammation{"Neuroinflammation"}
    CNR2 -->|"activates"| Neuroinflammation
    Inflammation{"Inflammation"}
    CNR2 -->|"activates"| Inflammation
    neurodegeneration["neurodegeneration"]
    CNR2 -->|"implicated in"| neurodegeneration
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"activates"| CNR2
    APP["APP"]
    APP -->|"expressed in"| CNR2
    TAU["TAU"]
    TAU -->|"activates"| CNR2
    NEUROINFLAMMATION["NEUROINFLAMMATION"]
    NEUROINFLAMMATION -->|"activates"| CNR2
    style CNR2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (30)

Target	Relation	Type	Str
Alzheimer	activates	disease	0.65
Dementia	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Inflammation	activates	disease	0.65
Alzheimer	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
C3AR1	associated_with	gene	0.60
ADCY2	associated_with	gene	0.60
GRM2	associated_with	gene	0.60
CXCL12	associated_with	gene	0.60
CXCL8	associated_with	gene	0.60
NPY	associated_with	gene	0.60
MTNR1A	interacts_with	gene	0.60
NPY	interacts_with	gene	0.60
MTNR1A	binds_to	gene	0.60
NPY	binds_to	gene	0.60
ALZHEIMER'S DISEASE	interacts_with	gene	0.60
HUB GENES	associated_with	gene	0.60
ALS	associated_with	disease	0.60
Alzheimer	associated_with	disease	0.60
CCR5	interacts_with	gene	0.50
CXCL8	interacts_with	gene	0.50
C3AR1	interacts_with	gene	0.50
GRM2	interacts_with	gene	0.50
CXCL12	interacts_with	gene	0.50
CCR5	associated_with	gene	0.50
CXCL12	co_expressed_with	gene	0.50
CXCL8	co_expressed_with	gene	0.50
NPY	co_mentioned	gene	0.40

Incoming (22)

Source	Relation	Type	Str
APP	expressed_in	gene	0.60
TAU	activates	gene	0.60
CXCL12	associated_with	gene	0.60
ADCY2	associated_with	gene	0.60
GRM2	associated_with	gene	0.60
NPY	associated_with	gene	0.60
CXCL8	associated_with	gene	0.60
CCR5	associated_with	gene	0.60
MTNR1A	associated_with	gene	0.60
C3AR1	associated_with	gene	0.60
ADCY2	interacts_with	gene	0.60
C3AR1	interacts_with	gene	0.60
CCR5	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
GENES	associated_with	gene	0.60
AND	associated_with	gene	0.60
MTNR1A	interacts_with	gene	0.50
C3AR1	co_expressed_with	gene	0.50
CCR5	co_expressed_with	gene	0.50
adcy2	interacts_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
CB2R deletion effects on GVHD-induced behavioral changes	validation	graft versus host disease	0.900	0.00	C57BL/6 mice with B10.BR donor	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CNR2

Understanding Entity Pages

Wiki Pages (9)

CNR2 Gene - Cannabinoid Receptor 2 (CB2)

Endocannabinoid System Dysfunction Hypothesis in Parkinson's Disease

Endocannabinoid System in Neurodegeneration

GRM2 Gene

Cannabinoid Receptor Neurons

Diacylglycerol Lipase Beta (DAGLβ)

IGC-AD1 for Agitation in Alzheimer's Disease (NCT05543681)

Endocannabinoid CB2 Receptor Neurons