CCR5

Understanding Entity Pages

This page aggregates everything SciDEX knows about CCR5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

CCR5 is a gene implicated in neurodegeneration research. Key relationships include: activates, interacts with, therapeutic target. Associated with Als, Cardiovascular, Dementia. Connected to 73 entities in the SciDEX knowledge graph.

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graph TD
    CCR5["<b>CCR5</b>"]
    PI3K["PI3K"]
    CCR5 -->|"activates"| PI3K
    Huntington{"Huntington"}
    CCR5 -->|"activates"| Huntington
    Tauopathy{"Tauopathy"}
    CCR5 -->|"activates"| Tauopathy
    Neurodegeneration{"Neurodegeneration"}
    CCR5 -->|"inhibits"| Neurodegeneration
    Dementia{"Dementia"}
    CCR5 -->|"interacts with"| Dementia
    Als{"Als"}
    CCR5 -->|"interacts with"| Als
    Ms{"Ms"}
    CCR5 -->|"interacts with"| Ms
    CCR5 -->|"therapeutic target"| Als
    CCR5 -->|"therapeutic target"| Ms
    Stroke{"Stroke"}
    CCR5 -->|"inhibits"| Stroke
    Ischemia{"Ischemia"}
    CCR5 -->|"therapeutic target"| Ischemia
    Cardiovascular{"Cardiovascular"}
    CCR5 -->|"therapeutic target"| Cardiovascular
    CCL3["CCL3"]
    CCL3 -->|"activates"| CCR5
    CCL4["CCL4"]
    CCL4 -->|"activates"| CCR5
    CCL5["CCL5"]
    CCL5 -->|"activates"| CCR5
    CCL5 -->|"inhibits"| CCR5
    AKT["AKT"]
    AKT -->|"activates"| CCR5
    PI3K -->|"activates"| CCR5
    LC3B["LC3B"]
    LC3B -->|"interacts with"| CCR5
    FIS1["FIS1"]
    FIS1 -->|"interacts with"| CCR5
    MFN2["MFN2"]
    MFN2 -->|"interacts with"| CCR5
    MICROGLIA["MICROGLIA"]
    MICROGLIA -->|"therapeutic target"| CCR5
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    NEURODEGENERATIVE_DISEASES -->|"activates"| CCR5
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"inhibits"| CCR5
    style CCR5 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0