gene

GRM2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GRM2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

109Connections

0Hypotheses

0Analyses

50Outgoing

47Incoming

Summary

GRM2 Gene

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🧬 Gene Info

Gene Symbol	GRM2
Protein Type	Receptor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	Brainstem, Amygdala, Cortex, Hippocampus, Cerebellum
Pathways	Wnt, Oxidative Phosphorylation
Ensembl ID	ENSG00000164082
GeneCards	GRM2
Human Protein Atlas	GRM2
Associated Diseases	ALS, Alzheimer, Inflammation, Neuroinflammation, Ptsd
Interactions	WNT1, IL13, WNT11, TNFRSF1B, TNFRSF13C, CXCL12
KG Connections	109 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    GRM2["GRM2"]
    Alzheimer["Alzheimer"]
    Als["Als"]
    Neuroinflammation["Neuroinflammation"]
    NPY["NPY"]
    CXCL8["CXCL8"]
    CCR5["CCR5"]
    MTNR1A["MTNR1A"]
    ALZHEIMER["ALZHEIMER"]
    CNR2["CNR2"]
    C3AR1["C3AR1"]
    WNT1["WNT1"]
    ASTROCYTE["ASTROCYTE"]
    CRH["CRH"]
    WNT["WNT"]
    ADRA2B["ADRA2B"]
    IL13["IL13"]
    CHRNE["CHRNE"]
    WNT11["WNT11"]
    GRM2 <-->|"interacts"| Alzheimer
    GRM2 <-->|"interacts"| Als
    GRM2 -->|"activates"| Als
    GRM2 -.-|"associated"| Als
    GRM2 -.-|"associated"| Neuroinflammation
    GRM2 -.-|"associated"| NPY
    GRM2 -.-|"associated"| CXCL8
    GRM2 -.-|"associated"| CCR5
    GRM2 -.-|"associated"| MTNR1A
    GRM2 <-->|"interacts"| ALZHEIMER
    GRM2 -.-|"associated"| CNR2
    GRM2 -.-|"associated"| C3AR1
    GRM2 -->|"activates"| WNT1
    GRM2 -->|"activates"| ASTROCYTE
    GRM2 -->|"expressed in"| CRH
    GRM2 -->|"activates"| WNT
    GRM2 -->|"expressed in"| ADRA2B
    GRM2 -->|"activates"| IL13
    GRM2 -->|"expressed in"| CHRNE
    GRM2 -->|"activates"| WNT11
    style GRM2 fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (62)

Target	Relation	Type	Str
Ptsd	associated_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Als	activates	disease	0.65
Als	associated_with	disease	0.65
Neuroinflammation	associated_with	disease	0.65
ALS	interacts_with	disease	0.65
ALS	activates	disease	0.65
ALS	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
NPY	associated_with	gene	0.60
CXCL8	associated_with	gene	0.60
CCR5	associated_with	gene	0.60
MTNR1A	associated_with	gene	0.60
CNR2	associated_with	gene	0.60
C3AR1	associated_with	gene	0.60
WNT1	activates	gene	0.60
CRH	expressed_in	gene	0.60
ADRA2B	expressed_in	gene	0.60
IL13	activates	gene	0.60
CHRNE	expressed_in	gene	0.60
WNT11	activates	gene	0.60
GRIN3B	expressed_in	gene	0.60
TNFRSF1B	activates	gene	0.60
TNFRSF13C	activates	gene	0.60
HCRTR1	expressed_in	gene	0.60
HAPLN1	associated_with	gene	0.60
P2RY12	associated_with	gene	0.60
CXCL12	associated_with	gene	0.60
CDH23	associated_with	gene	0.60
ADCY2	associated_with	gene	0.60
CHRM4	expressed_in	gene	0.60
MYO7A	activates	gene	0.60
Rb	expressed_in	protein	0.60
MTNR1A	interacts_with	gene	0.60
NPY	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
ASTROCYTE	activates	gene	0.60
WNT	activates	gene	0.60
GABA	expressed_in	gene	0.60
CYTOKINES	activates	gene	0.60
Wnt	activates	pathway	0.60
Microglia	activates	cell_type	0.60
Astrocyte	activates	cell_type	0.60
MITOCHONDRIA	associated_with	gene	0.60
GENES	activates	gene	0.60
Oxidative Phosphorylation	associated_with	pathway	0.60
Cytokine	activates	protein	0.60
Chemokine	associated_with	protein	0.60
Alzheimer	associated_with	disease	0.60

Incoming (47)

Source	Relation	Type	Str
CXCL12	associated_with	gene	0.60
ADCY2	associated_with	gene	0.60
CHRM4	expressed_in	gene	0.60
MYO7A	activates	gene	0.60
CDH23	associated_with	gene	0.60
MTNR1A	associated_with	gene	0.60
NPY	associated_with	gene	0.60
C3AR1	associated_with	gene	0.60
CCR5	associated_with	gene	0.60
CXCL8	associated_with	gene	0.60
CNR2	associated_with	gene	0.60
WNT1	activates	gene	0.60
TNFRSF1B	activates	gene	0.60
GRIN3B	expressed_in	gene	0.60
CRH	expressed_in	gene	0.60
HCRTR1	expressed_in	gene	0.60
WNT11	activates	gene	0.60
ADRA2B	expressed_in	gene	0.60
IL13	activates	gene	0.60
CHRNE	expressed_in	gene	0.60
P2RY12	associated_with	gene	0.60
HAPLN1	associated_with	gene	0.60
TNFRSF13C	activates	gene	0.60
ADCY2	interacts_with	gene	0.60
CXCL12	interacts_with	gene	0.60
GENES	associated_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
AND	associated_with	gene	0.60
ALZHEIMER'S DISEASE	interacts_with	gene	0.60
HUB GENES	associated_with	gene	0.60
CYTOKINES	activates	gene	0.60
WNT	activates	gene	0.60
AND	expressed_in	gene	0.60
NEUROINFLAMMATION	associated_with	gene	0.60
MITOCHONDRIA	associated_with	gene	0.60
ASTROCYTE	activates	gene	0.60
MTNR1A	interacts_with	gene	0.50
CNR2	interacts_with	gene	0.50
CCR5	interacts_with	gene	0.50
CXCL8	interacts_with	gene	0.50
C3AR1	interacts_with	gene	0.50
acetylcholine	expressed_in	disease	0.50
CXCL12	co_expressed_with	gene	0.50
CXCL8	co_expressed_with	gene	0.50
adcy2	interacts_with	gene	0.50
GABA	expressed_in	gene	0.50
P2Y12	associated_with	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

GRM2

Understanding Entity Pages

Summary

Wiki Pages (21)

GRM2 Gene

Cerebellar Purkinje Cells in Motor Coordination

mGluR2 Protein — Glutamate Metabotropic Receptor 2

GRM4 Gene

BAFFR Gene (TNFRSF13C)

WNT11 Gene

GRM7 Gene

GRM6 Gene

CNR2 Gene - Cannabinoid Receptor 2 (CB2)

mGluR2 Protein

Layer 4 Granule Cells

WNT1 Gene

Metabotropic Glutamate (mGluR) Receptor Neurons

Cerebellar Nodulus Neurons

Metabotropic Glutamate Receptor 2 (mGluR2) Neurons

mGluR3 (GRM3) Neurons

mGluR2 (GRM2) Neurons

Metabotropic Glutamate Receptor Modulator Therapy for Neurodegeneration

GRM3 — Glutamate Metabotropic Receptor 3