Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about AMYLOID_BETA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | AMYLOID_BETA |
| Key Genes/Proteins | ANTIMICROBIAL_PEPTIDE, BACTERIAL_AMYLOIDS, NFKB, C3, CASPASE2, APP |
| Related Diseases | ALZHEIMER'S_DISEASE, PLAQUES, CELL_DEATH |
| Related Pathways | CA2_HOMEOSTASIS |
Knowledge base pages for this entity
graph TD
AMYLOID_BETA["AMYLOID_BETA"]
AMYLOID_BETA -->|"contributes to"| PLAQUES["PLAQUES"]
AMYLOID_BETA -->|"inhibits"| synaptic_plasticity["synaptic_plasticity"]
AMYLOID_BETA -->|"regulates"| calcium["calcium"]
AMYLOID_BETA -->|"activates"| NFKB["NFKB"]
AMYLOID_BETA -->|"activates"| C3["C3"]
AMYLOID_BETA -->|"inhibits"| CA2_HOMEOSTASIS["CA2_HOMEOSTASIS"]
AMYLOID_BETA -->|"activates"| CASPASE2["CASPASE2"]
AMYLOID_BETA -->|"causes"| CELL_DEATH["CELL_DEATH"]
MICROGLIA["MICROGLIA"] -->|"interacts"| AMYLOID_BETA
APP["APP"] -->|"regulates"| AMYLOID_BETA
PRESENILIN["PRESENILIN"] -->|"regulates"| AMYLOID_BETA
IGF1R["IGF1R"] -->|"inhibits"| AMYLOID_BETA
ASK1["ASK1"] -->|"regulates"| AMYLOID_BETA| Target | Relation | Type | Str |
|---|---|---|---|
| ALZHEIMER'S_DISEASE | causes | disease | 0.80 |
| ANTIMICROBIAL_PEPTIDE | is | protein | 0.80 |
| PLAQUES | contributes_to | phenotype | 0.72 |
| NFKB | activates | protein | 0.64 |
| C3 | activates | protein | 0.64 |
| CA2_HOMEOSTASIS | inhibits | pathway | 0.64 |
| CASPASE2 | activates | protein | 0.64 |
| CELL_DEATH | causes | phenotype | 0.56 |
| Source | Relation | Type | Str |
|---|---|---|---|
| BACTERIAL_AMYLOIDS | induces_misfolding_of | protein | 0.80 |
| MICROGLIA | interacts_with | cell_type | 0.64 |
| APP | regulates | gene | 0.64 |
| PRESENILIN | regulates | gene | 0.64 |
| CYP46A1 | associated_with | gene | 0.60 |
| IGF1R | inhibits | protein | 0.56 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.542
neurodegeneration | 2026-04-12 | 0 hypotheses
neurodegeneration | 2026-04-02 | 2 hypotheses Top: 0.490
neurodegeneration | 2026-04-02 | 0 hypotheses
neurodegeneration | 2026-04-02 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||