gene

IGF1R

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IGF1R: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

340Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

IGF1R is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, regulates. Associated with AD, ALS, Als. Connected to 173 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	IGF1R
Chromosome	15q26.3
Protein Type	Receptor
Function	Ligand (IGF1 or IGF2) binding to extracellular α-subunits
Amino Acids	706 aa
Exons	21
Pathways	PI3K, MAPK
Ensembl ID	ENSG00000140443
GeneCards	IGF1R
Human Protein Atlas	IGF1R
Exon 1-2	5' UTR and signal peptide
Exons 3-11	α-subunit (extracellular ligand-binding domain)
Exons 12-21	β-subunit (transmembrane and intracellular domains)
Alternative splicing	Produces variants with tissue-specific expression
Associated Diseases	AD, ALS, Alzheimer, Alzheimer's disease, DIABETES
Interactions	TNF, IGF1, BDNF, PDGFRB, PI3K, RELA
KG Connections	340 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    IGF1R["IGF1R"]
    IGF1R -->|"target for"| Als["Als"]
    IGF1R -->|"regulates"| Fibrosis["Fibrosis"]
    IGF1R -->|"regulates"| Inflammation["Inflammation"]
    IGF1R -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    IGF1R -->|"activates"| Alzheimer["Alzheimer"]
    IGF1R -->|"activates"| Ms["Ms"]
    IGF1R -->|"expressed in"| Cancer["Cancer"]
    IGF1R -->|"interacts"| Tumor["Tumor"]
    NINJURIN2["NINJURIN2"] -->|"interacts"| IGF1R
    HSPG2["HSPG2"] -->|"regulates"| IGF1R
    BDNF["BDNF"] -->|"activates"| IGF1R
    PDGFRB["PDGFRB"] -->|"activates"| IGF1R
    DAG1["DAG1"] -->|"regulates"| IGF1R
    BCL_2["BCL-2"] -->|"regulates"| IGF1R
    BAD["BAD"] -->|"regulates"| IGF1R
    IGF1["IGF1"] -->|"activates"| IGF1R
    PI3K["PI3K"] -->|"activates"| IGF1R
    AKT["AKT"] -->|"activates"| IGF1R

Outgoing (245)

Target	Relation	Type	Str
cancer	therapeutic_target	disease	0.92
ERK	activates	protein	0.90
MAPK	activates	pathway	0.90
transcriptional activation	regulates	process	0.88
neuropathic pain	therapeutic_target	disease	0.87
apoptosis	inhibits	process	0.87
Skin Fibrosis	drives	phenotype	0.80
neuronal survival	regulates	biological_process	0.80
Aβ-induced neuronal death	inhibits	phenotype	0.80
Aβ-induced inflammation	inhibits	phenotype	0.80
Alzheimer's disease	implicated_in	disease	0.80
Als	therapeutic_target	disease	0.75
PIK3CA	interacts_with	gene	0.70
neurodegeneration	activates	disease	0.70
Skin Fibrosis	involved_in	phenotype	0.70
oxidative stress response	participates_in	pathway	0.70
Fibrosis	regulates	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Inflammation	regulates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Alzheimer	activates	disease	0.65
Ms	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
Ms	activates	disease	0.65
Fibrosis	activates	disease	0.65
Als	inhibits	disease	0.65
Alzheimer	associated_with	disease	0.65
Cancer	expressed_in	disease	0.65
Tumor	interacts_with	disease	0.65
Ms	therapeutic_target	disease	0.65
Ms	inhibits	disease	0.65
Diabetes	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Cardiovascular	expressed_in	disease	0.65
ALS	regulates	disease	0.65
Cancer	interacts_with	disease	0.65
Inflammation	interacts_with	disease	0.65
Colorectal Cancer	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
NEURONAL_SURVIVAL	regulates	phenotype	0.64
EGR1	activates	protein	0.64
PI3K_AKT	activates	pathway	0.64
NEUROINFLAMMATION	regulates	phenotype	0.64
DAG1	regulates	gene	0.60
BAD	regulates	gene	0.60
TNF	activates	gene	0.60
IGF1	activates	gene	0.60
BDNF	activates	gene	0.60

Incoming (95)

Source	Relation	Type	Str
FST	binds_to	protein	0.95
Separating Microneedles	downregulates	compound	0.85
5-fluorouracil	downregulates	drug	0.80
NINJURIN2	interacts_with	protein	0.72
HSPG2	regulates	gene	0.60
BDNF	activates	gene	0.60
PDGFRB	activates	gene	0.60
DAG1	regulates	gene	0.60
BAD	regulates	gene	0.60
IGF1	activates	gene	0.60
PI3K	activates	gene	0.60
AKT	activates	gene	0.60
BDNF	associated_with	gene	0.60
EGR1	activates	gene	0.60
IGF1	associated_with	gene	0.60
PIK3CA	interacts_with	gene	0.60
MMP9	therapeutic_target	gene	0.60
PPARA	therapeutic_target	gene	0.60
SRC	associated_with	gene	0.60
BCL2L1	expressed_in	gene	0.60
MAP2K1	associated_with	gene	0.60
TNF	activates	gene	0.60
IL6	interacts_with	gene	0.60
PTGS2	interacts_with	gene	0.60
BAX	activates	gene	0.60
AKT1	interacts_with	gene	0.60
PI3K	inhibits	gene	0.60
OVERVIEW	interacts_with	gene	0.60
PI3K	associated_with	gene	0.60
BAD	activates	entity	0.60
DAG1	activates	entity	0.60
HSPG2	activates	entity	0.60
AKT	interacts_with	entity	0.60
EGR1	interacts_with	entity	0.60
CDK5	therapeutic_target	gene	0.60
CACNA1C	therapeutic_target	gene	0.60
MMP2	therapeutic_target	gene	0.60
ESR1	therapeutic_target	gene	0.60
ESR1	associated_with	gene	0.60
TAU	therapeutic_target	gene	0.60
GSK3B	therapeutic_target	gene	0.60
APP	interacts_with	gene	0.60
CACNA1C	interacts_with	gene	0.60
CS	associated_with	gene	0.60
IGF1	expressed_in	gene	0.60
BCL-2	regulates	gene	0.60
MYOD	inhibits	gene	0.60
ROS	regulates	gene	0.60
APOPTOSIS	regulates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

IGF1R

Understanding Entity Pages

Summary

Wiki Pages (21)

IGF1R Gene

cbs-psp-daily-action-plan

Insulin Signaling in Parkinson's Disease

IGF-1 Signaling Pathway in Neurodegeneration

Receptor-Mediated Transcytosis (RMT)

VPS35 Retromer Dysfunction Parkinson's Disease Causal Chain

Expanded to 3000+ words

IGF2 Protein (Insulin-like Growth Factor 2)

Pituitary Somatotrophs Neurodegeneration

PSP Neurotrophic Factor Dysfunction

Metabolic Dysfunction and Insulin Signaling Impairment Pathway

IGF2R Protein

IGF1 Gene

Brain Insulin Signaling

IGF2 (Insulin-Like Growth Factor 2)

IRS-1 (Insulin Receptor Substrate 1)

Insulin-Like Growth Factor 1 Protein

IGF-1 Receptor Neurons

Insulin-Like Growth Factor 1 Receptor Protein