disease

ATHEROSCLEROSIS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATHEROSCLEROSIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2103Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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Disease Info

Associated Genes	APP, BMAL1, HIF1A, LDLR
Therapeutic Agents	CURCUMIN
KG Connections	222 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Pathway Diagram

graph TD
    ATHEROSCLEROSIS["ATHEROSCLEROSIS"] -->|"promotes"| MACROPHAGE["MACROPHAGE"]
    style MACROPHAGE fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    ATHEROSCLEROSIS["ATHEROSCLEROSIS"] -->|"promotes"| MACROPHAGES["MACROPHAGES"]
    style MACROPHAGES fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    ATHEROSCLEROSIS["ATHEROSCLEROSIS"] -->|"causes"| ENDOTHELIAL["ENDOTHELIAL"]
    style ENDOTHELIAL fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    ATHEROSCLEROSIS["ATHEROSCLEROSIS"] -->|"promotes"| PI3K["PI3K"]
    style PI3K fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    ATHEROSCLEROSIS["ATHEROSCLEROSIS"] -.->|"reduces"| INFLAMMATION["INFLAMMATION"]
    style INFLAMMATION fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    ATHEROSCLEROSIS["ATHEROSCLEROSIS"] -.->|"reduces"| LDLR["LDLR"]
    style LDLR fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    ATHEROSCLEROSIS["ATHEROSCLEROSIS"] -->|"expressed in"| DIABETES["DIABETES"]
    style DIABETES fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    C1Q["C1Q"] -->|"associated"| ATHEROSCLEROSIS["ATHEROSCLEROSIS"]
    style C1Q fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    C1QA["C1QA"] -->|"associated"| ATHEROSCLEROSIS["ATHEROSCLEROSIS"]
    style C1QA fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    C1QC["C1QC"] -->|"associated"| ATHEROSCLEROSIS["ATHEROSCLEROSIS"]
    style C1QC fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    MACROPHAGE_1["MACROPHAGE"] -->|"contributes to"| ATHEROSCLEROSIS["ATHEROSCLEROSIS"]
    style MACROPHAGE_1 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    APOE["APOE"] -->|"associated"| ATHEROSCLEROSIS["ATHEROSCLEROSIS"]
    style APOE fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style ATHEROSCLEROSIS fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (596)

Target	Relation	Type	Str
Lipid Metabolism	regulates	pathway	1.00
Senescence	associated_with	disease	1.00
Inflammasome	activates	pathway	1.00
Cholesterol	regulates	pathway	1.00
Inflammation	associated_with	disease	1.00
Inflammation	inhibits	disease	1.00
Inflammation	therapeutic_target	disease	1.00
Inflammation	causes	disease	1.00
Inflammation	activates	disease	1.00
Inflammation	contributes_to	disease	1.00
Lipid Metabolism	associated_with	pathway	1.00
Microrna	regulates	pathway	1.00
Oxidative Stress	activates	pathway	1.00
Cholesterol	inhibits	pathway	1.00
Mtor	therapeutic_target	pathway	1.00
Cholesterol	associated_with	pathway	0.95
Cardiovascular Morbidity And Mortality	causes	phenotype	0.95
Inflammation	implicated_in	disease	0.95
Cardiovascular Diseases	causes	disease	0.95
Vascular Remodelling	associated_with	process	0.95
Alzheimer'S Disease	risk_factor_for	disease	0.95
Cardiovascular Disease	causes	disease	0.95
Coronary Artery Disease	causes	disease	0.90
Stroke	risk_factor_for	disease	0.90
Oxidative Stress	therapeutic_target	pathway	0.90
Epigenetic	therapeutic_target	pathway	0.90
Nf-Κb	inhibits	pathway	0.90
Cholesterol	activates	pathway	0.90
Oxidative Stress	treats	pathway	0.90
Lipid Metabolism	therapeutic_target	pathway	0.90
Mtor	activates	pathway	0.90
Lipid Metabolism	activates	pathway	0.90
Autophagy	activates	pathway	0.90
Heart Failure	causes	disease	0.85
Cardiovascular	activates	disease	0.85
Cardiovascular	associated_with	disease	0.85
Vascular Brain Injury	causes	process	0.85
Cardiovascular	therapeutic_target	disease	0.85
MACROPHAGES	activates	cell_type	0.80
Alzheimer's Disease	risk_factor_for	disease	0.80
Differentiation	implicated_in	pathway	0.80
Differentiation	regulates	pathway	0.80
Mtor	inhibits	pathway	0.80
Immune Response	therapeutic_target	pathway	0.80
Nf-Κb	therapeutic_target	pathway	0.80
Toll-Like Receptor	activates	pathway	0.80
Angiogenesis	regulates	pathway	0.80
Nf-Κb	regulates	pathway	0.80
Mapk	therapeutic_target	pathway	0.80
Cholesterol	therapeutic_target	pathway	0.80

Incoming (1507)

Source	Relation	Type	Str
INFLAMMATION	implicated_in	gene	1.00
OXIDATIVE STRESS	therapeutic_target	gene	1.00
CYTOKINES	activates	gene	1.00
Als	therapeutic_target	disease	1.00
Als	regulates	disease	1.00
GENES	therapeutic_target	gene	1.00
INFLAMMATION	associated_with	gene	1.00
NF-ΚB	inhibits	gene	1.00
APOE	inhibits	gene	1.00
INFLAMMATION	activates	gene	1.00
Als	activates	disease	1.00
INFLAMMATION	therapeutic_target	gene	1.00
GENES	regulates	gene	1.00
Aging	associated_with	disease	1.00
APOE	activates	gene	1.00
INFLAMMATION	inhibits	gene	1.00
AGING	associated_with	gene	1.00
OXIDATIVE STRESS	activates	gene	1.00
MICRORNAS	regulates	gene	1.00
LDL	inhibits	gene	1.00
LDL	activates	gene	1.00
INFLAMMATION	contributes_to	gene	1.00
Cancer	associated_with	disease	1.00
Als	associated_with	disease	1.00
Diabetes	associated_with	disease	1.00
CANCER	associated_with	gene	1.00
Cardiovascular	associated_with	disease	1.00
INFLAMMATION	causes	gene	1.00
AGING	activates	gene	1.00
APOE	associated_with	gene	1.00
TNF	therapeutic_target	gene	0.95
Cardiac	associated_with	disease	0.95
STROKE	associated_with	gene	0.95
APRIL	inhibits	protein	0.95
Cigarette Smoking	risk_factor_for	drug	0.95
AUTOPHAGY	activates	gene	0.95
EPSIN2	promotes	gene	0.95
AMPK	activates	gene	0.95
EPSIN1	promotes	gene	0.95
MIRNAS	regulates	gene	0.95
GENES	associated_with	gene	0.95
Bap	associated_with	compound	0.95
C1Q	risk_factor_for	gene	0.95
Cigarette Smoking	causes	drug	0.95
GPR146 Deficiency	protects_against	phenotype	0.95
SPP1	contributes_to	protein	0.95
NF-ΚB	therapeutic_target	gene	0.95
GENES	activates	gene	0.95
Als	inhibits	disease	0.95
Inflammation	promotes	process	0.95

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity