concept

CHLOROQUINE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHLOROQUINE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

113Connections

0Hypotheses

0Analyses

50Outgoing

29Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	CHLOROQUINE
Key Genes/Proteins	CTSD, SLC2A4, CASP3, GLUT4, CTSB, TSC2
Related Diseases	IMMUNE RESPONSE, CANCER, AUTOPHAGY

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    CHLOROQUINE["CHLOROQUINE"]
    CHLOROQUINE -->|"modulates"| Tumor_Associated_Macrophages["Tumor-Associated Macrophages"]
    CHLOROQUINE -->|"modulates"| Antitumor_Immune_Response["Antitumor Immune Response"]
    CHLOROQUINE -->|"inhibits"| mitophagy["mitophagy"]
    CHLOROQUINE -->|"inhibits"| Autophagy["Autophagy"]
    CHLOROQUINE -->|"regulates"| MAP1LC3B["MAP1LC3B"]
    CHLOROQUINE -->|"activates"| CTSD["CTSD"]
    CHLOROQUINE -->|"regulates"| IMMUNE_RESPONSE["IMMUNE RESPONSE"]
    CANCER["CANCER"] -->|"regulates"| CHLOROQUINE

Outgoing (84)

Target	Relation	Type	Str
CTSD	activates	gene	0.65
IMMUNE RESPONSE	regulates	phenotype	0.65
SLC2A4	associated_with	gene	0.50
CASP3	associated_with	gene	0.50
GLUT4	associated_with	gene	0.50
CTSB	associated_with	gene	0.50
TSC2	associated_with	gene	0.50
ATM	associated_with	gene	0.50
ATG16L1	associated_with	gene	0.50
PINK1	associated_with	gene	0.50
OPTN	associated_with	gene	0.50
PTEN	associated_with	gene	0.50
AUTOPHAGY	associated_with	phenotype	0.45
P2RY12	associated_with	gene	0.45
APOE	associated_with	gene	0.45
MTOR	associated_with	gene	0.45
PI3K	associated_with	gene	0.45
AKT	associated_with	gene	0.45
CHOLESTEROL	associated_with	phenotype	0.45
SQSTM1	associated_with	gene	0.45
ABCA1	associated_with	gene	0.45
AMPK	associated_with	gene	0.45
ATG5	associated_with	gene	0.45
ULK1	associated_with	gene	0.45
ALS	associated_with	disease	0.45
LAMP2	associated_with	gene	0.45
MACROPHAGES	associated_with	cell_type	0.45
UBIQUITIN	associated_with	protein	0.45
MELANOMA	associated_with	disease	0.45
NLRP3	associated_with	gene	0.45
CASP1	associated_with	gene	0.45
LAMP1	associated_with	gene	0.45
IL1B	associated_with	gene	0.45
TNF	associated_with	gene	0.45
BECN1	associated_with	gene	0.45
HIF1A	associated_with	gene	0.45
ROS	associated_with	phenotype	0.45
RAPAMYCIN	associated_with	drug	0.45
CANCER	associated_with	disease	0.45
HUNTINGTIN	associated_with	protein	0.45
DEMENTIA	associated_with	disease	0.45
NEURON	associated_with	cell_type	0.45
DNMT1	associated_with	gene	0.45
TFEB	associated_with	gene	0.45
ATG7	associated_with	gene	0.45
GABA	associated_with	phenotype	0.45
APOPTOSIS	associated_with	phenotype	0.45
ISCHEMIA	associated_with	disease	0.45
PARKIN	associated_with	gene	0.45
BCL2	associated_with	gene	0.45

Incoming (29)

Source	Relation	Type	Str
CANCER	regulates	disease	0.65
ATHEROSCLEROSIS	associated_with	disease	0.45
ATORVASTATIN	associated_with	drug	0.45
GLIOBLASTOMA	associated_with	disease	0.45
HYDROXYCHLOROQUINE	associated_with	drug	0.45
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	disease	0.45
FRONTOTEMPORAL DEMENTIA	associated_with	disease	0.45
DNA DAMAGE RESPONSE	associated_with	pathway	0.45
DOPAMINERGIC NEURONS	associated_with	cell_type	0.45
SUBSTANTIA NIGRA	associated_with	brain_region	0.45
IMMUNE RESPONSE	associated_with	phenotype	0.45
AKT	associated_with	gene	0.45
APOE	associated_with	gene	0.45
AUTOPHAGY	associated_with	phenotype	0.45
ABCA1	associated_with	gene	0.45
ALS	associated_with	disease	0.45
AMPK	associated_with	gene	0.45
ATG5	associated_with	gene	0.45
ATP	associated_with	phenotype	0.45
CASP1	associated_with	gene	0.45
BBB	associated_with	phenotype	0.45
BECN1	associated_with	gene	0.45
CANCER	associated_with	disease	0.45
ATG7	associated_with	gene	0.45
APOPTOSIS	associated_with	phenotype	0.45
BCL2	associated_with	gene	0.45
AUTOPHAGOSOMES	associated_with	organelle	0.45
SPINAL MUSCULAR ATROPHY	associated_with	disease	0.45
GLIAL FIBRILLARY ACIDIC PROTEIN	associated_with	biomarker	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CHLOROQUINE

Understanding Entity Pages

Wiki Pages (20)

Autophagy Mechanisms

rapamycin-tauopathy

Ferroptotic Neurons

Endosomal Sorting Defects in Neurodegeneration

Shared Proteinostasis Failure in Alzheimer's and Parkinson's Disease

PSP Ferroptosis and Iron-Dependent Cell Death

Retromer Stabilizers for Neurodegeneration

CBS Autophagy-Lysosomal Pathway Dysfunction

PICALM→Clathrin-Mediated Endocytosis→Aβ Accumulation→AD Causal Chain

CTSD (Cathepsin D)

Endosomal-Lysosomal Trafficking in CBS/PSP

LYST Gene — Lysosomal Trafficking Regulator

Multiple Sclerosis Mechanistic Pathway

cGAS-STING Pathway in Alzheimer's Disease

DEPTOR

Autosis Pathway in Neurodegeneration

Pituitary Intermedia Cells

Xenophagy in Neurodegeneration