gene

BCL2L12

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BCL2L12: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

14Connections

0Hypotheses

0Analyses

11Outgoing

3Incoming

Summary

BCL2L12 - anti-apoptotic BCL-2 family protein in neurodegeneration

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🧬 Gene Info

Gene Symbol	BCL2L12
Aliases	BCL2-L-12, BCL-R, NRE-1
Chromosome	19q13.33
Function	is a member of the BCL-2 protein family with predominantly anti-apoptotic functions.
Primary Expression	glioblastoma, emerging research suggests important roles in neuronal survival and neurodegeneration
Molecular Weight	34 kDa
Amino Acids	297 aa
Exons	5
Pathways	NF-κB signaling
UniProt ID	Q9Y235
NCBI Gene ID	83696
GeneCards	BCL2L12
Human Protein Atlas	BCL2L12
Gene Name	BCL2 Like 12
Protein Length	297 amino acids
Associated Diseases	Alzheimer's disease, Parkinson's disease
Interactions	P38, STAT6, NF-ΚB, INFLAMMATION
KG Connections	14 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: BCL2L12 — AlphaFold Q9Y235 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

BCL2L12 Gene

gene · 1024 words

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Genes

index · 271 words

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Pathway Diagram

graph TD
    BCL2L12["<b>BCL2L12</b>"]
    Ms{"Ms"}
    BCL2L12 -->|"activates"| Ms
    Leukemia{"Leukemia"}
    BCL2L12 -->|"activates"| Leukemia
    Apoptosis(["Apoptosis"])
    BCL2L12 -->|"expressed in"| Apoptosis
    neurodegeneration["neurodegeneration"]
    BCL2L12 -->|"implicated in"| neurodegeneration
    BCL2["BCL2"]
    BCL2 -->|"expressed in"| BCL2L12
    BCL2_FAMILY["BCL2 FAMILY"]
    BCL2_FAMILY -->|"associated with"| BCL2L12
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"expressed in"| BCL2L12
    style BCL2L12 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (11)

Target	Relation	Type	Str
Apoptosis	expressed_in	pathway	0.70
Ms	activates	disease	0.65
Leukemia	activates	disease	0.65
Inflammation	activates	disease	0.65
P38	activates	gene	0.60
BCL2	expressed_in	gene	0.60
STAT6	activates	gene	0.60
NF-ΚB	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
Mapk	activates	pathway	0.60
Nf-Κb	activates	pathway	0.60

Incoming (3)

Source	Relation	Type	Str
APOPTOSIS	expressed_in	gene	0.70
BCL2	expressed_in	gene	0.60
BCL2 FAMILY	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found