concept

BCL2 FAMILY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BCL2 FAMILY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

175Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

BCL2 FAMILY is a concept in neurodegeneration research. Key relationships include: therapeutic target, activates, regulates. Associated with Aging, Als, Alzheimer. Connected to 125 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	BCL2 FAMILY
Key Genes/Proteins	BCL2, CANCER
Related Diseases	Als, Cancer, Lymphoma, Tumor, Ms
Related Pathways	Apoptosis

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    BCL2_FAMILY["BCL2 FAMILY"]
    BCL2_FAMILY -->|"regulates"| apoptosis["apoptosis"]
    BCL2_FAMILY -->|"inhibits"| Tumor["Tumor"]
    BCL2_FAMILY -->|"inhibits"| Ms["Ms"]
    BCL2_FAMILY -->|"target for"| Parkinson["Parkinson"]
    BCL2_FAMILY -->|"target for"| Als["Als"]
    BCL2_FAMILY -->|"target for"| Cancer["Cancer"]
    BCL2_FAMILY -->|"activates"| Leukemia["Leukemia"]
    BCL2["BCL2"] -->|"inhibits"| BCL2_FAMILY
    BNIP3["BNIP3"] -->|"regulates"| BCL2_FAMILY
    CTSL["CTSL"] -->|"regulates"| BCL2_FAMILY
    FOXO3["FOXO3"] -->|"target for"| BCL2_FAMILY
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"target for"| BCL2_FAMILY
    MCL1["MCL1"] -->|"regulates"| BCL2_FAMILY

Outgoing (123)

Target	Relation	Type	Str
BCL2	activates	gene	0.80
Als	therapeutic_target	disease	0.75
Cancer	therapeutic_target	disease	0.75
Lymphoma	therapeutic_target	disease	0.75
CANCER	therapeutic_target	gene	0.70
Apoptosis	therapeutic_target	pathway	0.70
BCL2	therapeutic_target	gene	0.70
Tumor	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Ms	activates	disease	0.65
Leukemia	activates	disease	0.65
Als	regulates	disease	0.65
Ms	interacts_with	disease	0.65
Leukemia	expressed_in	disease	0.65
Ms	therapeutic_target	disease	0.65
Cancer	regulates	disease	0.65
Inflammation	inhibits	disease	0.65
Alzheimer	expressed_in	disease	0.65
Aging	expressed_in	disease	0.65
Tauopathy	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Dementia	expressed_in	disease	0.65
Lymphoma	associated_with	disease	0.65
Leukemia	associated_with	disease	0.65
Als	implicated_in	disease	0.65
Tumor	activates	disease	0.65
Aging	therapeutic_target	disease	0.65
Als	activates	disease	0.65
Leukemia	therapeutic_target	disease	0.65
ALS	expressed_in	disease	0.65
Lymphoma	regulates	disease	0.65
Aging	causes	disease	0.65
MDM2	inhibits	gene	0.60
P53	inhibits	gene	0.60
Apoptosis	inhibits	pathway	0.60
MCL1	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
OXIDATIVE STRESS	therapeutic_target	gene	0.60
AUTOPHAGY-RELATED GENES	regulates	gene	0.60
PIK3R1	regulates	gene	0.60
BECN1	regulates	gene	0.60
STAT3	regulates	gene	0.60
MICRORNAS	regulates	gene	0.60
CTSB	regulates	gene	0.60
MITOPHAGY	therapeutic_target	gene	0.60
HIF1A	regulates	gene	0.60
FOXO1	therapeutic_target	gene	0.60
PIK3C3	regulates	gene	0.60

Incoming (52)

Source	Relation	Type	Str
BCL2	inhibits	gene	0.60
BCL2	regulates	gene	0.60
BNIP3	regulates	gene	0.60
CTSL	regulates	gene	0.60
FOXO3	therapeutic_target	gene	0.60
PARKINSON'S DISEASE	therapeutic_target	gene	0.60
MCL1	regulates	gene	0.60
BCL2	associated_with	gene	0.60
BCL2	interacts_with	gene	0.60
BCL2	expressed_in	gene	0.60
MCL1	therapeutic_target	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
BCL2	therapeutic_target	gene	0.60
CANCER	regulates	gene	0.60
AGING	expressed_in	gene	0.60
MICROGLIA	inhibits	gene	0.60
TREM2	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
INFLAMMATION	inhibits	gene	0.60
CD44	associated_with	gene	0.60
ERK	associated_with	gene	0.60
LGALS3	regulates	gene	0.60
AKT	associated_with	gene	0.60
BCL2	activates	gene	0.60
BCL2L13	activates	gene	0.60
BAX	implicated_in	gene	0.60
AND	inhibits	gene	0.60
TAUOPATHY	expressed_in	gene	0.60
DISEASE-ASSOCIATED MICROGLIA	expressed_in	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
BRAIN INFLAMMATION	inhibits	gene	0.60
CTSB	regulates	gene	0.60
FOXO1	therapeutic_target	gene	0.60
AUTOPHAGY-RELATED GENES	regulates	gene	0.60
EIF2AK2	therapeutic_target	gene	0.60
HIF1A	regulates	gene	0.60
MITOPHAGY	therapeutic_target	gene	0.60
GENES	regulates	gene	0.60
PIK3C3	regulates	gene	0.60
OXIDATIVE STRESS	therapeutic_target	gene	0.60
BECN1	regulates	gene	0.60
MITOCHONDRIA	therapeutic_target	gene	0.60
DEMENTIA	expressed_in	gene	0.60
APOPTOSIS	associated_with	gene	0.60
APOPTOSIS	causes	gene	0.60
BAK	regulates	gene	0.60
microglia	inhibits	cell_type	0.50
inflammation	inhibits	pathway	0.50
apoptosis	associated_with	process	0.50
cancer	regulates	disease	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

BCL2 FAMILY

Understanding Entity Pages

Summary

Wiki Pages (20)

NTF4 Protein

GLI1 — GLI Family Zinc Finger 1

lmx1b

Combination Therapy Synergies for CBS/PSP

Estrogen Signaling in Neurodegeneration

YAP/TAZ Signaling Pathway in Neurodegeneration

BOK — BCL2 Family Ovarian Killer

MCL1 Gene - Myeloid Cell Leukemia 1

CYTC

BCL2 Gene

BBC3

BAX Gene

BCLXL Gene

SPHK1 — Sphingosine Kinase 1

YAP1 — Yes-Associated Protein 1

WDR73 Gene

NOXA Protein

Cytochrome c Protein