protein

BECN1PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BECN1PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Beclin-1 is a core autophagy scaffold protein encoded by BECN1. It organizes class III phosphatidylinositol 3-kinase (PI3K-III) complexes that initiate autophagosome nucleation and trafficking.

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🔬 Protein Info

Gene Symbol	BECN1PROTEIN
Full Name	Beclin-1
Protein Type	Protein
Function	is a core autophagy scaffold protein encoded by BECN1.
UniProt ID	Search UniProt
GeneCards	BECN1PROTEIN
Human Protein Atlas	BECN1PROTEIN
Associated Diseases	AD, ALI, Als, Alzheimer, Alzheimer's disease
Known Drugs/Compounds	crocin, HCQ, Isorhapontigenin, nicotine, rapamycin, RAPAMYCIN
Interactions	ABCD3, ACAT1, ACETYL-COA, ACHE, ACOX1, ACTB
KG Connections	3054 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: BECN1PROTEIN — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Beclin-1 Protein

protein · 557 words

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Pathway Diagram

graph TD
    BECN1PROTEIN["BECN1PROTEIN"]
    neurodegeneration["neurodegeneration"]
    BECN1PROTEIN -->|"implicated_in"| neurodegeneration
    style BECN1PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning BECN1PROTEIN in their description or question text

No additional research found