protein

BECN1PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BECN1PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Beclin-1 is a core autophagy scaffold protein encoded by BECN1. It organizes class III phosphatidylinositol 3-kinase (PI3K-III) complexes that initiate autophagosome nucleation and trafficking.

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🔬 Protein Info

Gene Symbol	BECN1
Full Name	Beclin-1
Protein Type	Protein
Function	BECN1 encodes beclin-1, a key regulator of autophagy—a cellular process for degrading and recycling damaged organelles, protein aggregates, and intracellular pathogens.
Molecular Weight	60 kDa
Pathways	Akt, Apoptosis, Autophagy, Car-T, Epigenetic
UniProt ID	Q9Y5P6
Ensembl ID	ENSG00000126581
GeneCards	BECN1
Human Protein Atlas	BECN1
Associated Diseases	AD, ALI, ALS, AMI, Alzheimer
Known Drugs/Compounds	RAPAMYCIN, SORAFENIB, rapamycin, nicotine, crocin, HCQ
Interactions	C9ORF72, NBR1, G3BP1, TOLLIP, SQSTM1, NDP52
KG Connections	2944 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: BECN1PROTEIN — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Beclin-1 Protein

protein · 557 words

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Pathway Diagram

graph TD
    BECN1PROTEIN["BECN1PROTEIN"]
    neurodegeneration["neurodegeneration"]
    BECN1PROTEIN -->|"implicated_in"| neurodegeneration
    style BECN1PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found