NOTCH3

Understanding Entity Pages

This page aggregates everything SciDEX knows about NOTCH3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

NOTCH3 is a gene implicated in neurodegeneration research. Key relationships include: expressed in, contributes to, activates. Associated with Aging, Als, Autoimmune. Connected to 47 entities in the SciDEX knowledge graph.

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graph TD
    NOTCH3["<b>NOTCH3</b>"]
    Als{"Als"}
    NOTCH3 -->|"activates"| Als
    Neuroinflammation{"Neuroinflammation"}
    NOTCH3 -->|"regulates"| Neuroinflammation
    Autoimmune{"Autoimmune"}
    NOTCH3 -->|"regulates"| Autoimmune
    Inflammation{"Inflammation"}
    NOTCH3 -->|"regulates"| Inflammation
    Multiple_Sclerosis{"Multiple Sclerosis"}
    NOTCH3 -->|"regulates"| Multiple_Sclerosis
    Ms{"Ms"}
    NOTCH3 -->|"activates"| Ms
    Dementia{"Dementia"}
    NOTCH3 -->|"contributes to"| Dementia
    Aging{"Aging"}
    NOTCH3 -->|"contributes to"| Aging
    NOTCH3 -->|"contributes to"| Als
    Stroke{"Stroke"}
    NOTCH3 -->|"contributes to"| Stroke
    Glioblastoma{"Glioblastoma"}
    NOTCH3 -->|"expressed in"| Glioblastoma
    NOTCH3 -->|"expressed in"| Als
    MTOR["MTOR"]
    MTOR -->|"expressed in"| NOTCH3
    TLR4["TLR4"]
    TLR4 -->|"activates"| NOTCH3
    PI3K["PI3K"]
    PI3K -->|"expressed in"| NOTCH3
    SOD2["SOD2"]
    SOD2 -->|"activates"| NOTCH3
    AKT["AKT"]
    AKT -->|"expressed in"| NOTCH3
    SOD1["SOD1"]
    SOD1 -->|"activates"| NOTCH3
    CANCER["CANCER"]
    CANCER -->|"activates"| NOTCH3
    EP300["EP300"]
    EP300 -->|"regulates"| NOTCH3
    style NOTCH3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0