concept

TGF-BETA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TGF-BETA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

157Connections

2Hypotheses

2Analyses

31Outgoing

50Incoming

0Experiments

6Debates

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💡 Concept Info

Name	TGF-BETA
Key Genes/Proteins	AKT, APOE, APP, BACE1
Related Diseases	Als, ALZHEIMER'S DISEASE, Atherosclerosis, ATHEROSCLEROSIS, CANCER

Pathway Diagram

graph TD
    TGF_BETA["TGF-BETA"]
    TGF_BETA -->|"activates"| HEPATOCELLULAR_CARCINOMA["HEPATOCELLULAR CARCINOMA"]
    TGF_BETA -->|"activates"| COLORECTAL_CANCER["COLORECTAL CANCER"]
    TGF_BETA -->|"activates"| METASTASIS["METASTASIS"]
    TGF_BETA -->|"activates"| FIBROSIS["FIBROSIS"]
    TGF_BETA -->|"implicated in"| CANCER["CANCER"]
    TGF_BETA -->|"activates"| AGING["AGING"]
    TGF_BETA -->|"activates"| EGFR["EGFR"]
    TGF_BETA -->|"regulates"| FERROPTOSIS["FERROPTOSIS"]
    CYTOKINES["CYTOKINES"] -->|"regulates"| TGF_BETA
    CANCER -->|"regulates"| TGF_BETA
    TNF["TNF"] -->|"activates"| TGF_BETA
    IL_6["IL-6"] -->|"regulates"| TGF_BETA
    INFLAMMATION["INFLAMMATION"] -->|"activates"| TGF_BETA
    VEGF["VEGF"] -->|"activates"| TGF_BETA

Outgoing (31)

Target	Relation	Type	Str
Angiogenesis	correlates_with	process	0.92
alpha-synuclein induced toxicity	mediates	process	0.85
PULMONARY HYPERTENSION	involved_in	entity	0.80
microglial TREM2 activation	modulates	process	0.70
angiogenic properties	correlates_with	process	0.70
neuroinflammation	activates	mechanism	0.70
Atherosclerosis	inhibits	disease	0.65
Als	inhibits	disease	0.65
Macrophage	inhibits	cell_type	0.60
APOE	inhibits	gene	0.60
IL-6	inhibits	gene	0.60
Tgf-Beta	activates	pathway	0.60
CANCER	associated_with	disease	0.58
HEPATOCELLULAR CARCINOMA	associated_with	disease	0.44
AGING	regulates	process	0.30
CYTOKINES	regulates	protein	0.30
STROKE	regulates	disease	0.30
NF-KB	interacts_with	gene	0.30
AUTOPHAGY	inhibits	process	0.30
CANCER	activates	disease	0.30
AGING	activates	process	0.30
METASTASIS	associated_with	process	0.30
METASTASIS	activates	process	0.30
COLORECTAL CANCER	associated_with	disease	0.30
COLORECTAL CANCER	activates	disease	0.30
HEPATOCELLULAR CARCINOMA	activates	disease	0.30
FIBROSIS	activates	disease	0.30
EGFR	activates	gene	0.30
FERROPTOSIS	regulates	process	0.30
ROS	regulates	protein	0.30
HEPATOCELLULAR CARCINOMA	inhibits	disease	0.30

Incoming (126)

Source	Relation	Type	Str
TREM2	regulated_by	gene	0.80
CANCER	regulates	gene	0.70
CYTOKINES	regulates	gene	0.70
TNF	activates	gene	0.70
BMPR1B	participates_in	gene	0.70
CYTOKINES	activates	gene	0.70
PARKINSON'S DISEASE	activates	gene	0.60
PARKINSON	activates	gene	0.60
IL-6	activates	gene	0.60
BCL-2	treats	gene	0.60
6-OHDA	treats	gene	0.60
Tumor	activates	disease	0.60
Parkinson	activates	disease	0.60
Als	treats	disease	0.60
APOPTOSIS	treats	gene	0.60
APOE	inhibits	gene	0.60
IL-6	regulates	gene	0.60
CANCER	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
P53	contributes_to	gene	0.60
INFLAMMATION	protects_against	gene	0.60
P53	protects_against	gene	0.60
Cancer	regulates	disease	0.60
Als	protects_against	disease	0.60
Inflammation	protects_against	disease	0.60
Longevity	protects_against	disease	0.60
Cirrhosis	activates	disease	0.60
Hypertension	activates	disease	0.60
Fibrosis	activates	disease	0.60
BMP2	interacts_with	gene	0.60
TGF-BETA	activates	gene	0.60
IL-6	inhibits	gene	0.60
BMP4	interacts_with	gene	0.60
TNF	regulates	gene	0.60
ABCD3	regulates	gene	0.60
MITOCHONDRIA	therapeutic_target	gene	0.60
APOPTOSIS	activates	gene	0.60
BCL-2	therapeutic_target	gene	0.60
Hepatocellular Carcinoma	therapeutic_target	disease	0.60
Als	therapeutic_target	disease	0.60
Carcinoma	therapeutic_target	disease	0.60
Hepatitis	therapeutic_target	disease	0.60
Autoimmune	therapeutic_target	disease	0.60
CYTOKINES	expressed_in	gene	0.60
LRP1	activates	gene	0.60
NGF	treats	gene	0.60
FAS	treats	gene	0.60
EGF	activates	gene	0.60
VEGF	activates	gene	0.60
Atherosclerosis	inhibits	disease	0.55

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
BBB leak induces secondary pericyte senescence through TGF-b	0.560	neurodegeneration	Does pericyte senescence drive BBB break
Early Postnatal TGF-beta Signaling Establishes Lifelong Regi	0.500	neuroinflammation	How do regional, age, and sex-dependent