Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about BST1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | BST1 |
| Full Name | Bone Marrow Stromal Cell Antigen 1 |
| Aliases | Page for BST1 Gene |
| Chromosome | 4p15.2 |
| Function | BST1/CD157 is expressed primarily on the surface of hematopoietic cells, including neutrophils, monocytes, and bone marrow stromal cells. |
| Primary Expression | Bone marrow, hematopoietic cells, brain (low) |
| Molecular Weight | 33.9 kDa |
| Amino Acids | 310 aa |
| UniProt ID | Q15833 |
| NCBI Gene ID | 682 |
| Ensembl ID | ENSG00000105552 |
| OMIM | 615197 |
| GeneCards | BST1 |
| Human Protein Atlas | BST1 |
| Associated Diseases | ALS, Alzheimer's disease, Parkinson's disease, neurodegeneration |
| KG Connections | 21 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["BST1"]
N1["Parkinson's Disease"]
N0 -->|"therapeutic target"| N1
N2["CR2"]
N0 -->|"causes"| N2
N3["ERBB1"]
N0 -->|"causes"| N3
N4["GPNMB"]
N0 -->|"causes"| N4
N5["IL34"]
N0 -->|"causes"| N5
N6["PILRA"]
N0 -->|"causes"| N6
N7["SHARPIN"]
N0 -->|"causes"| N7
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classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
classDef drug fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
classDef cell_type fill:#2a1a2a,stroke:#ab47bc,color:#e0e0e0
classDef phenotype fill:#2a2a1a,stroke:#ffa726,color:#e0e0e0
classDef process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
classDef biological_process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
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classDef entity fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef therapeutic fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
classDef index fill:#1a1a2a,stroke:#7986cb,color:#e0e0e0
class N0 gene
class N1 disease
class N2 gene
class N3 gene
class N4 gene
class N5 gene
class N6 gene
class N7 gene| Target | Relation | Type | Str |
|---|---|---|---|
| Parkinson's Disease | therapeutic_target | disease | 0.85 |
| Parkinson'S Disease | therapeutic_target | disease | 0.85 |
| CR2 | causes | gene | 0.60 |
| ERBB1 | causes | gene | 0.60 |
| GPNMB | causes | gene | 0.60 |
| IL34 | causes | gene | 0.60 |
| PILRA | causes | gene | 0.60 |
| SHARPIN | causes | gene | 0.60 |
| STX6 | causes | gene | 0.60 |
| TREM2 | causes | gene | 0.60 |
| neurodegeneration | causes | disease | 0.60 |
| LRRK2 | biomarker_for | gene | 0.60 |
| RIT2 | biomarker_for | gene | 0.60 |
| SNCA | biomarker_for | gene | 0.60 |
| TMEM175 | biomarker_for | gene | 0.60 |
| Alzheimer's disease | causes | disease | 0.60 |
| Parkinson's disease | causes | disease | 0.60 |
| ALS | causes | disease | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||