Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SHARPIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | SHARPIN |
| Full Name | SHANK Associated RH Domain Interactor |
| Chromosome | 8q24.3 |
| Function | is a core component of the linear ubiquitin chain assembly complex (LUBAC), the only known E3 ligase capable of generating methionine-1 (M1)-linked polyubiquitin chains. |
| Primary Expression | both neurons and glial cells, though its functional roles differ by cell type: in neurons, SHARPIN primarily functions in postsyn |
| Molecular Weight | 40 kDa |
| Amino Acids | 387 aa |
| Pathways | NF-κB |
| UniProt ID | Q9H0F6 |
| NCBI Gene ID | 81858 |
| Ensembl ID | ENSG00000179526 |
| OMIM | 611885 |
| GeneCards | SHARPIN |
| Human Protein Atlas | SHARPIN |
| Associated Diseases | ALS, Alzheimer, Alzheimer's disease, Ms, Parkinson's disease |
| Interactions | UBIQUITIN, NF-ΚB |
| KG Connections | 51 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
SHARPIN["<b>SHARPIN</b>"]
Ms{"Ms"}
SHARPIN -->|"associated with"| Ms
Alzheimer{"Alzheimer"}
SHARPIN -->|"associated with"| Alzheimer
Als{"Als"}
SHARPIN -->|"associated with"| Als
APOE["APOE"]
SHARPIN -->|"associated with"| APOE
PLCG2["PLCG2"]
SHARPIN -->|"associated with"| PLCG2
ALZHEIMER["ALZHEIMER"]
SHARPIN -->|"associated with"| ALZHEIMER
CHRNE["CHRNE"]
SHARPIN -->|"associated with"| CHRNE
AND["AND"]
SHARPIN -->|"associated with"| AND
AMYLOID["AMYLOID"]
SHARPIN -->|"associated with"| AMYLOID
neurodegeneration["neurodegeneration"]
SHARPIN -->|"implicated in"| neurodegeneration
APP["APP"]
APP -->|"associated with"| SHARPIN
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
ALZHEIMER_S_DISEASE -->|"associated with"| SHARPIN
NDUFAF7["NDUFAF7"]
NDUFAF7 -->|"associated with"| SHARPIN
style SHARPIN fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | provides_data_for | dataset | 1.00 |
| Alzheimer'S Disease | therapeutic_target | disease | 0.85 |
| Alzheimer's Disease | therapeutic_target | disease | 0.80 |
| Ms | associated_with | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Als | inhibits | disease | 0.65 |
| Inflammation | treats | disease | 0.65 |
| APOE | associated_with | gene | 0.60 |
| PLCG2 | associated_with | gene | 0.60 |
| CHRNE | associated_with | gene | 0.60 |
| UBIQUITIN | interacts_with | gene | 0.60 |
| TNF | treats | gene | 0.60 |
| CYLD | associated_with | gene | 0.60 |
| UBIQUITIN | associated_with | gene | 0.60 |
| STX6 | causes | gene | 0.60 |
| TREM2 | causes | gene | 0.60 |
| neurodegeneration | causes | disease | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| AMYLOID | associated_with | gene | 0.60 |
| NF-ΚB | inhibits | gene | 0.60 |
| Nf-Κb | inhibits | pathway | 0.60 |
| Immune Response | interacts_with | pathway | 0.60 |
| FERROPTOSIS | regulates | gene | 0.60 |
| Autophagy | regulates | pathway | 0.60 |
| Ferroptosis | regulates | pathway | 0.60 |
| Apoptosis | regulates | pathway | 0.60 |
| Pyroptosis | regulates | pathway | 0.60 |
| Necroptosis | regulates | pathway | 0.60 |
| Alzheimer's disease | causes | disease | 0.60 |
| Parkinson's disease | causes | disease | 0.60 |
| ALS | causes | disease | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| benchmark_ot_ad_answer_key:SHARPIN | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | data_in | dataset | 1.00 |
| APP | associated_with | gene | 0.60 |
| NDUFAF7 | associated_with | gene | 0.60 |
| OTULIN | associated_with | gene | 0.60 |
| ATXN3 | causes | gene | 0.60 |
| BST1 | causes | gene | 0.60 |
| CR2 | causes | gene | 0.60 |
| ERBB1 | causes | gene | 0.60 |
| GPNMB | causes | gene | 0.60 |
| IL34 | causes | gene | 0.60 |
| PILRA | causes | gene | 0.60 |
| ALZHEIMER'S DISEASE | associated_with | gene | 0.60 |
| AUTOPHAGY | regulates | gene | 0.60 |
| APOPTOSIS | regulates | gene | 0.60 |
| PYROPTOSIS | regulates | gene | 0.60 |
| B4GALNT1 | causes | gene | 0.60 |
| benchmark_ot_ad_answer_key:SHARPIN | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||